干扰素调节因子(InterferonRegulatoryFactor,IRF)是一类参与机体内I型干扰素(IFN)及干扰素刺激基因(ISG)转录调控的转录调节因子家族。IRF3和IRF7属于IRF家族成员,是调节IFN和ISG表达的关键因子。IRF3和IRF7在宿主细胞抵抗病毒侵入,调节细胞生长和免疫应答反应中都扮演着十分重要的角色。 首先,我们通过检测了病
干扰素调节因子(IRF,interferon regulatory factor)是对干扰素基因表达具有转录调控作用的一种关键转录因子;IRF3和IRF7是IRF家族成员中,调节I型干扰素基因表达的关键基因。宿主细胞内PRRs识别入侵的病原微生物后,通过一系列信号通路激活下游IKKe与TBK.1基因;被激活的IKKe与TBK.1共同作用,随后使IRF3与IRF7磷酸化。磷酸化...
Deacetylation of specific lysine residues in the DNA-binding domain of the transcription factors IRF3 and IRF7 by SIRT1 is necessary for liquid–liquid phase separation and transactivation of type I interferons. SIRT1 agonists partially restored the impa
(2)取乳鼠小肠免疫组织化学法观察乳鼠小肠黏膜组织中IRF3,IRF7,IFN-β的表达;(3)免疫磁珠法分离乳鼠小肠黏膜上皮内淋巴细胞(Intraepithelial lymphocyte iEL)CD4~+T,CD8~+T采用Western blotting法检测细胞中IRF3,IRF7蛋白表达.结果:1,免疫组织化学法观测分析:模型组各时间点乳鼠小肠黏膜组织中IRF3,IRF7的表达量随着...
产品数据库 Introduction Description:pIRF3/IRF7 RE-Luc is designed for monitoring the induction of Interferon regulatory transcription factor (IRF)3&7.IRF3 is a member of the interferon regulatory transcription factor (IRF) family.IRF3 plays an important role in the innate immune system's response ...
IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434, 772–777 (2005). Article CAS Google Scholar Yan, N. & Chen, Z. J. Intrinsic antiviral immunity. Nat. Immunol. 13, 214–222 (2012). Article CAS Google Scholar McNab, F., Mayer-Barber, K.,...
Fish IRF3 up-regulates the transcriptional level of IRF1, IRF2, IRF3 and IRF7 in CIK cells Interferon Regulatory Factors (IRFs) belong to a family of transcription factor involved in transcriptional regulation of type I IFN and IFN-stimulated gen... X Xu,Q Lai,M Gu,... - 《Fish & She...
制造商IRF [International Rectifier] 网页http://www.irf.com 标志 类似零件编号 - IRF3709ZPBF 制造商部件名数据表功能描述 International RectifierIRF3709ZPBF 374Kb/12PHEXFET Power MOSFET IRF3709ZPBF 383Kb/13PHigh Frequency Synchronous Buck Converters for Computer Processor Power ...
红米平板 SE:https://u.jd.com/IrfsNMp酷比魔方掌玩mini:https://u.jd.com/I6ft7la---【1000-2000】推荐华为平板11.5s:https://u.jd.com/I6jXcFf小米平板7:https://u.jd.com/Irje8WG荣耀平板9:https://u.jd.com/Irf3M1biQOO Pad2:https://u.jd.com/I1jkEZ8三星A9+:https://u.jd.com/...