Effects of statins on adipose tissue inflammation: their inhibitory effect on MyD88-independent IRF3/IFN-beta pathway in macrophages. Arterioscler Thromb Vasc Biol 2008;28:871-7.M. Abe, M. Matsuda, H. Kobayashi et al., "Effects of statins on adipose tissue inflammation: their inhibitory effect...
2.干扰素(interferon,IFN) 具有干扰病毒复制的能力,故得名。其具有十分广泛的生物活性,在免疫应答和免疫调节中发挥重要作用,干扰素调节因子3(IRF3)重组蛋白也是主要的促炎细胞因子之一。干扰素分为:I型(7种,如IFN-α和IFN-β)和II型(仅有IFN-Y) 3.肿瘤坏死因子(tumor necrosis factor,TNF) ...
(IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of ...
Corrigendum to “Role of OGDH in Autophagy-IRF3-IFN-β pathway during classical swine fever virus infection” [Int. J. Biol. Macromol. 249 (2023) 126443 (BIOMAC 126443)] International Journal of Biological Macromolecules, Volume 250, 1 October 2023, Pages 127031 Sen Zeng, Wenhui Zhu, Zipeng...
3,4-二溴97%Anti-IFN-Beta 干扰素-β抗体(抗人)人免疫球蛋白G1(IgG1)酶联免疫吸附测定试剂盒 3,4-二溴70%Anti-IFN-Alpha 干扰素-α抗体(抗人)人免疫球蛋白G2(IgG2)酶联免疫吸附测定试剂盒 4-苄氧-3-氟98%Anti-IFN-Alpha 2b 干扰素α2b抗体人免疫球蛋白G3(IgG3)酶联免疫吸附测定试剂盒 2-苄氧96...
et al. Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells. Cancer Res. 67, 11133–11140 (2007). Article CAS PubMed Google Scholar Bunz, F. et al. Requirement for p53 and p21 to sustain G...
IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) ...
Viral infections trigger host innate immune responses, characterized by the production of type-I interferons (IFN) including IFNβ. IFNβ induces cellular antiviral defense mechanisms and thereby contributes to pathogen clearance. Accumulating evidence s
利用CTPS1条件缺失和IRF3脱酰胺或抗脱酰胺敲入小鼠,我们证明了CTPS1驱动的IRF3脱酰胺在体内对病毒感染的反应中限制了IFN的诱导。然而,在免疫激活过程中,糖原合成酶激酶3β(GSK3b)抑制CTPS1对IRF3的脱酰胺作用,从而促进IFN的诱导。这项工作证明了CTPS1如何独立于其在嘧啶合成中的作用来驯化先天免疫,从而将代谢酶的...