Neuroblastoma (NB), the most common solid extracranial cancer of childhood, displays a remarkable low expression of Major Histocompatibility Complex class I (MHC-I) and Antigen Processing Machinery (APM) molecules, including Endoplasmic...
Expression of MHC-I, IRF1 and IRF2 in NB cell lines.Silvia, LorenziMatteo, ForloniLoredana, CifaldiChiara, AntonucciArianna, CittiRenata, BoldriniMarco, PezzulloAurora, CastellanoVincenzo, RussoPierre, van der Bruggen
Previous studies revealed that BMDCs fromStat1−/−andIfnar−/−mice exhibit strongly reduced IL-12 p70 but not IL-12 p40 secretion41. Thus,Fam73bablation may improve type I IFN induction to promoteIl12aexpression. In contrast,Fam73bdeficiency caused a significant reduction in inducibleIfnbe...
Additionally, RNA-sequencing analysis showed that 2142–R8 treatment downregulated PD-L1, while the expression of major histocompatibility complex class I (MHC class I)-related genes and most of the IRF1 downstream remained unchanged, consistent with the data from KAT8-depleted cells (Fig. 7n,o ...
Additionally, RNA-sequencing analysis showed that 2142–R8 treatment downregulated PD-L1, while the expression of major histocompatibility complex class I (MHC class I)-related genes and most of the IRF1 downstream remained unchanged, consistent with the data from KAT8-depleted cells (Fig. 7n,o ...
The MHC class I-mediated antigen presentation pathway plays a critical role in antiviral immunity. Here we show that the MHC class I pathway is targeted by SARS-CoV-2. Analysis of the gene expression profile from COVID-19 patients as well as SARS-CoV-2 infected epithelial cell lines reveals...
[63]. The result further indicatedIRF1might play a role in the regulation of the expression ofMHC IIinH. bleekeri. Paradoxically,IRF1expression was significantly downregulated in both the head kidney and spleen after treatment with LPS and poly(I:C) at 48 h after induction. Similarly, in ...
Expression of MHC-I, IRF1, IRF2 and the NF-kB p65 subunit in primary NB lesions.Silvia, LorenziMatteo, ForloniLoredana, CifaldiChiara, AntonucciArianna, CittiRenata, BoldriniMarco, PezzulloAurora, CastellanoVincenzo, RussoPierre, van der Bruggen...
The MHC class I-mediated antigen presentation pathway plays a critical role in antiviral immunity. Here we show that the MHC class I pathway is targeted by SARS-CoV-2. Analysis of the gene expression profile from COVID-19 patients as well as SARS-CoV-2 i