这一成果不仅验证了ProteinMPNN与AlphaFold Multimer联合使用的有效性,还为纳米抗体的进化研究提供了有力的工具和方法。 具体来说,通过ProteinMPNN进行多次迭代定向进化,并利用AlphaFold Multimer对蛋白复合物进行评分以控制进化方向,我们成功筛选出了具有高亲和力的纳米抗体(Seq2)。与原始纳米抗体相比,Seq2序列与目标抗原...
摘要: Protein post-translational modification (PTM) is an essential cellular regulatory mechanism, and disruptions in PTM have been implicated in disease. PTMs are an active area of study in many fields, le关键词: Post-translational modification Phosphorylation Acetylation Text mining Protein-protein ...
Protein-protein interactionRESTful APIiPTMnet is a resource that combines rich information about protein post-translational modifications (PTM) from curated databases as well as text mining tools. Researchers can use the iPTMnet website to query, analyze and download the PTM data. In this chapter ...
Now we are facing an interesting challenge: given an uncharacterized protein sequence containing many K residues, which ones can accommodate two or more types of PTM, which ones only one, and which ones none? Results: To address this problem, a multi-label predictor called iPTM-mLys has been...
RESTful API for iPTMnet: An Integrated Resource for Protein Post-translational Modification Network Discoverydoi:10.1145/3233547.3233649Sachin GavaliJulie CowartChuming ChenKaren RossCathy H. WuACMInternational Conference on BioinformaticsHuang, H.; Arighi, C.N.; Ross, K.E.; Ren, J.; Li, G.; ...