了解干细胞研究的伦理考量非常重要。传统上，研究依赖于胚胎干细胞（ESC），这引发了对胚胎破坏的伦理担忧。而MSC 和 iPSC 提供了替代解决方案，绕过了这些担忧。间充质干细胞（MSC）：MSCs来源于各种成人组织，例如骨髓、脂肪组织和脐带，因其再生特性和免疫调节作用而备受关注。MSCs能够分化为成骨细胞、软骨细胞和...
近日，发表在Life Sci的一项研究iPSC-derived mesenchymal stromal cells stimulate neovascularization less than their primary counterparts聚焦于诱导多能干细胞（iPSCs）衍生的间充质基质细胞（iMSCs），对比了其与骨髓MSCs（BM-MSCs）对血管生成的影响，为细胞治疗开辟新路径。本研究中BM-MSCs取自患者股骨头，穿刺后...
近日,国际权威学术期刊Stem Cells International在线发表了题为“Advancements and Innovative Strategies in Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cell Therapy: A Comprehensive Review”的综述论文,该论文通讯作者为中源协和首席科学官张宇博士及其带领的研发团队,论文中详细描述并总结了iPSC分化为iPSC-MS...
多项研究表明,iPSCs可以通过多种分化策略分化为iPSC-MSCs。 研究综述:与组织来源的MSCs相比,iPSC-MSCs在增殖能力、免疫调节能力和生物学效率方面表现出更优越的特性。 基于在MSCs方面的研发优势,公司自研间充质干细胞新药VUM02注射液8个适应症处于临床试验申请的不同阶段,其中临床拟用于治疗失代偿期肝硬化、特发性肺...
Administering iPSC-MSCs altered phosphorylation and cellular localization of the T cell-specific kinase, Protein Kinase C theta (PKCθ), attenuated disease severity, and prolonged survival in a humanized mouse model of GvHD. Finally, we sevaluated a constellation of pro-inflammatory molecules on ...
近日,国际权威学术期刊Stem Cells International 在线发表了题为“Advancements and Innovative Strategies in Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cell Therapy: A Comprehensive Review”的综述论文,该论文通讯作者... 网页链接
Journal of Hematology & Oncology (2016) 9:43 DOI 10.1186/s13045-016-0273-2 LETTER TO THE EDITOR Open Access iPSC-derived mesenchymal stromal cells are less supportive than primary MSCs for co- culture of hematopoietic progenitor cells Theresa Vasko1,2†, Joana Frobel1,2†, Richard Lubbe...
Chemotherapy can significantly reduce follicle counts in ovarian tissues and damage ovarian stroma, causing endocrine disorder, reproductive dysfunction, and primary ovarian insufficiency (POI). Recent studies have suggested that extracellular vesicles (
Large extracellular vesicles iPSC-derived MSCs Tendinopathy Inflammatory regulation Macrophages 1. Introduction Tendinopathy is a progressive musculoskeletal disorder and is characterized by inflammation and degenerative changes in tendon, which leads to pain, swelling, and impaired performance [1]. However, ...