以 iPSC 衍生的 CAR-NK 为例,从脐血来源制备的通用型 CAR-NK 细胞虽然生产成本低于 CAR-T,但 NK 细胞在 PBMC 中比例较低,加之脐血获取不易,培养成本较之 T 细胞更高,使得应用受到了限制。 iPSC 利用其无限扩增及分化能力,诱导的 NK 细胞能最大程度地降低成本。如:iPSC 衍生的 CAR-NK 治疗的头部企业 Fa...
Human PBMCs were cultured with IL-2 (GMP-L02H14), IL-15 (GMP-L15H13), IL-18(IL8-H5114), IL-21 (GMP-L21H25). The result shows that they are functional and can promote the expansion of these cells with a reasonable cell viability. 03 脐带血(UCB)来源 从脐带血(UCB)中获得大量NK细胞...
CAR-T则通过改造的T细胞识别和消灭CD70阳性的肿瘤细胞,同时对BCMA、CD19等靶点具有作用。 CAR-NK利用改造的NK细胞对CD70阳性的肿瘤细胞进行识别和攻击,同时也对IL15、IL15R、TGFβ、CD19等靶点具有效果。融合蛋白通过蛋白质的结合,调节或抑制CD27、PDL1、CD70、CD47、SIRPα等靶点的信号传导。树突状细胞疫苗通过...
Bio-Techne能为您提供iPSC衍生的各类常见细胞研究完整的解决方案,包括iPSC-NK细胞、iPSC-巨噬细胞、iPSC-神经细胞、iPSC-胰岛细胞等。 iPSC-衍生的细胞产品解决方案 iPSC培养请点击: 干细胞和类器官培养,谁是 BME 中的佼佼者? 类器官技术、细胞治疗的关键来源 iPSC,应该如何培养? 干细胞的干性维持和分化,你知道...
CAR-NK利用改造的NK细胞对CD70阳性的肿瘤细胞进行识别和攻击,同时也对IL15、IL15R、TGFβ、CD19等靶点具有效果。融合蛋白通过蛋白质的结合,调节或抑制CD27、PDL1、CD70、CD47、SIRPα等靶点的信号传导。树突状细胞疫苗通过激活免疫系统,作用于CD70、CD19、CD40L等靶点的肿瘤细胞。RNA疫苗通过转染肿瘤细胞,表达CD70...
such as improved functionality of final iPSC-CAR-NK products. For example, gene editing can be applied to achieve better differentiation, expansion, and killing, improve resistance to the oppressive immune microenvironment and migration, which will process the application of iPSC-CAR-NK therapy in tr...
NK Cell Therapy Solutions Advance to clinical applications with CTS iPSC media and reagents Advancing induced pluripotent stem cell (iPSC) therapy research to clinical applications requires researchers to carefully select materials, as the quality of starting mat...
NK Cell Therapy Solutions Advance to clinical applications with CTS iPSC media and reagents Advancing induced pluripotent stem cell (iPSC) therapy research to clinical applications requires researchers to carefully select materials, as the quality of starting materials has a ...
uniform in composition and can be delivered off-the-shelf for the treatment of large numbers of patients. We direct the fate of master iPSC lines to create cells of the immune system, including NK cells, T cells, and CD34+ cells and are advancing a pipeline of off-the-shelf cellular immu...
This antigen-specific effector function of human NK cells is mediated by the IgG Fc receptor CD16A (Fc纬RIIIA). Preclinical and clinical studies indicate that increasing the binding affinity and avidity of CD16A for antibodies improves the therapeutic potential of ADCC. CD64 (Fc纬RI), ...