To address this, we have developed iProt-Sub, a powerful bioinformatics tool for the accurate prediction of protease-specific substrates and their cleavage sites. Importantly, iProt-Sub represents a significantly advanced version of its successful predecessor, PROSPER. It provides optimized cleavage ...
iProt-Sub: a comprehensive package for accurately mapping and predicting protease-specific substrates and cleavage sitesdoi:10.1093/bib/bby028proteasesubstratecleavage sitesequence analysismachine learningfive-step ruleJiangning SongYanan WangFuyi Li
Using unhydroxylated collagen I produced in transgenic plants, we investigated the role of hydroxyproline in the receptorbinding properties of collagen. We show that α[sub 2]β[sub 1] but not α[sub 1]β[sub 1] mediates cell adhesion to unhydroxylated collagen. Soluble recombinant α[sub ...