Differences in protocols across groups may play a part in this apparent controversy. In particular, the two studies that reported a reduction with aspirin used single-point LDF as opposed to the more reliable LDI. More recently, Ramsay et al. (2002) found in a placebo-controlled study that ...
The purpose of this study was to compare the reduction in cutaneous sensation following two iontophoresis protocols with the same 40 mA*min dosage to a sham treatment. Both iontophoresis treatments used 2% lidocaine HCL and were delivered with a high amplitude/short duration (HASD) or a low ...
Based on the overall analysis, it can be concluded that the examined iontophoresis protocols did not cause undesired changes to the skin. Although in protocols 3-2 and 5-1, increases in EI and/or TEWL values were observed at the first time point, these changes were not of such a nature ...