Given the ability of ionizable lipids to enhance endosomal escape in a context of lipid nanoparticles (LNP), here, we provide the first report on the effect of an ionizable lipid conjugate on siRNA endosomal escape, tissue distribution, efficacy, and toxicity in vivo. After developing a ...
Ionizable lipid-1 | MedChemExpress (MCE) 英文名称: 总访问: 117 国产/进口: 进口 半年访问: 20 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 5 mg; 10 mg; 25 mg 最后更新: 2024-11-4 货号: HY-156630 CAS 号: 2055939-68-7 参考报价: 2900; 4600; 9300 立即询价 电话咨询 ...
mRNA delivery is achieved via viral or non-viral vector delivery systems. The non-viral delivery system, such as lipid nanoparticles (LNPs), is considered the most effective delivery platform. Due to the recently approved three mRNA vaccines (SPIKEVAX (mRNA1273), COMIRNATY (BNT162b2), ARCoV...
For ionizable poorly soluble drugs, a solvent-assisted active loading technology was developed to use miscible solvent assist drugs to go cross the lipid membrane, which was easier than the preceding way20. This facile approach was powerful in sweeping away the obstacle of poorly soluble drugs; ...
Ionizable lipid-containing lipid nanoparticles (LNPs) as a non-viral vector with good safety and potency have been considered as an ideal delivery system for gene therapy. The screening of ionizable lipid libraries with common features but diverse struct