ion-molecule reactionsnitrogenreaction rate constantswater/ He ++H 2OHe ++NH 3C ++H 2OC ++NH 3The first measurements of ion—polar-molecule reaction rate constants at very low temperatures are presented. They have been obtained using the CRESU (cine_.tique de reactions en ecoulement super...
Consequently, small molecule correctors of dysregulated ion channel trafficking are important therapeutics (Boyle et al., 2014). Genetically-encoded molecules that can either up-regulate or down-regulate surface density of ion channels have utility as research tools and potential therapeutics (Kanner, ...
The binding of a polar macromolecule to a large ion channel is studied theoretically, paying special attention to the influence of external conditions (applied voltage and ion strength of solution). The molecule behavior in bound state is considered as random thermal fluctuations within a limited fra...
The voltage required to sweep the ions to the conductors before a significant number of them recombine or stick to a neutral molecule is usually under 100 volts and is often just a few volts depending on the dimensions of the chamber. The resulting current is extremely low and detecting indivi...
A Lewis structure is a type of diagram that shows how the valence electrons are organized around an atom or molecule. Lewis structures help to create a simplified model of how the electrons are organized. Electrons are shown as dots and shared electrons in a covalent bond are shown as lines...
Collision rate constants have been calculated for ion-molecule reactions toSu, TPhillips Lab.Viggiano, A. APaulson, J. FSu, T., Viggiano, A.A., Paulson, J.F.: The effect of the dipole-induced dipole potential on ion polar molecule collision rate constants. J. Chem. Phys. 96(7), ...
Calcium orthophosphates (CaPs), as hydroxyapatite (HAP) in bones and teeth are the most important biomineral for humankind. While clusters in CaP nucleation have long been known, their speciation and mechanistic pathways to HAP remain debated. Evidently,
Chemical standards of sterol lipids were purchased from J&K Scientific (Shanghai, China), Avanti Polar Lipids (Alabaster, USA), Steraloids (Newport, RI, USA), and Sigma-Aldrich (St. Louis, MO, USA). Acetic acid was purchased from Fisher Scientific (Morris Plains, NJ, USA). Picolinic acid...
We recently showed9 that the RV-mediated depletion of ER Ca2+ activates an ER Ca2+ sensor protein called stromal interaction molecule 1 (STIM1) and STIM1 in turn induces Ca2+ influx through store-operated calcium entry (SOCE), a homeostatic cellular mechanism to maintain ER Ca2+ levels. We...
An ion-pair is created when a charged drug molecule associates with an oppositely charged counterion through noncovalent interactions.18., 20. To promote ion-pairing between a drug and a counterion, an excess of the counterion can be administered with the drug, which would force even weak ion-...