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Red highlights show the conserved glycines in the signature sequence TVGYG, found in the potassium ion channel KcsA. Yellow highlights show amino acids that are chemically similar. As the filter sequence becomes less conserved, the channels lose their selectivity for K+ over Na+ and become more...
Also as shown previously, the K+ channel blocker (Fig. 9b, light brown) greatly reduced the US-mediated cur- rents. Thus, US elicited K+ current flowing through the TREK-1 ion channel also in this modified setup, and so a presence of a solid substrate below a cell is not required ...
Excitable exposed to channel blocking agents (D; local anesthetics and antiarrhythmic drugs) show a progressive reduction of peak current when repetitively depolarized (use dependence). Thus, with repetitive excitation, use dependence reflects a net rightward shift in the balance between unblocked channe...
In the current study, we demonstrated that NLRP1 inflammasome is activated under acidosis, and ASIC-BK channel K+ signal mediates NLRP1 inflammasome activation induced by extracellular acidosis, which is accountable for acidosis-induced cortical neuronal injury. Inflammation is an innate immune response...
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LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev 62:381–404 Article CAS PubMed PubMed Central Google Scholar Xia YQ, Hua RJ, Juan C, Zhong ZH, Tao CS, Fang R, Lin H, Rui G, Yong C (2018) SIRT6 depletion sensitizes human hepatoma cells to ...
Letter OPEN doi:10.1038/nature17953 Ion-induced nucleation of pure biogenic particles Jasper Kirkby1,2, Jonathan Duplissy3,4, Kamalika Sengupta5, Carla Frege6, Hamish Gordon2, Christina Williamson1†, Martin Heinritzi1,7, Mario Simon1, Chao Yan3, João Almeida1,2, ...
This revealed that the decreased current amplitude was due to significantly faster inactivation kinetics already at −40 mV (Fig. 3e). KWVe11fu.1r-tVhe4r91aIssbeeshseadvewdhseimthielarrltyhetofuWncTticohnaanl npehlsen(doatytapensotobshseorwvned). in TEVC experiments were due to changes...