Diiodination of acetylsalicylic acid in the 3 and 5 positions causes an increase in the antihemostatic effect as measured by bleeding times. Diiodosalicylic acid has no demonstrable activity. The increase in potency of diiodoacetyl-salicylic acid over acetylsalicylic acid is not paralleled by its ...
The N-hydroxysuccinimide ester of 4-azidosalicylic acid, a photoactivable heterobifunctional reagent, can be radioiodinated. The low efficiency (3%) of the radioiodination by a previously published method ( I. Ji and T. H. Ji, 1982, Anal. Biochem. 121, 286–289) has been increased to 63...