Recombinant murinized PD-1 antibody forin vivouse Anti-mPD-1-mIgG1e3 InvivoFit™is arecombinantmurinized anti-mouse monoclonal antibody (mAb) featuring the variable region of the previously described anti-mPD-1 RMP1-14 mAb [1, 2]. The original RMP1-14 hybridoma was obtained by immunizin...
Antibody against mouse PD-1 (mouse IgG1e3 isotype D265A - effectorless) Anti-mPD-L1 Antibodies against PD-L1 (mouse IgG1e3 D265A isotype) Anti-mTIGIT Antibody against mouse TIGIT (mouse IgG2a isotype) Lymphocyte markers Anti-mCD3 Antibody against mouse CD3 (mouse IgG2a isotype) ...
9 BE0273 29F.1A12 InVivoMab anti-mouse PD-1 (CD279) 10 BP0101 10F.9G2 InVivoPlus anti-mouse PD-L1 (B7-H1) 11 BE0131 9H10 InVivoMab anti-mouse CTLA-4 (CD152) 12 BE0061 2.43 InVivoMab anti-mouse CD8α 13 BE0164 9D9 InVivoMab anti-mouse CTLA-4 (CD152) 14 BE0085 C1.1...
17A(+) GDL T cells were observed in skin cell suspensions derived from IMQ-treated PD-1KO mice (versus WT controls), suggesting that the lack of PD-1 has a functional effect not only on alphabeta T cells, but also on GDL T cells, and that PD-1 may play a regulatory role in PsD...
Anti-PD-L1-mIgG1e3 InvivoFit™ was generated by recombinant DNA technology so that it is ~85% murine (constant region). Importantly, its constant region contains a point mutation D265A (a replacement of aspartic acid by alanine at position 265), resulting in the complete loss of cytolyti...
(Tregs) via C-C motif chemokine 2 (CCL2); and express programmed death ligand 1/2 (PD-L1/L2) and CD80/86 (B7-1/2) on their cell surfaces to inhibit immune effector cell activation10. A comprehensive understanding of tumor-associated immune cells is a prerequisite for the ultimate ...
Initially considered impractical because of instability and immunogenicity, mRNA has become a focal point in therapeutics because of advancements in stabilizing modifications and delivery systems. This has led to its potential to replace plasmid DNA or recombinant proteins [303]. Moreover, the widespread...
Therapeutic-ultrasound (TUS) Prostate cancer Human tumor suppressor gene (hSef-b) Xenograft model, Mouse models Therapeutic ultrasound, considered safe for clinical applications The results suggested that hSef-b acts in a cell autonomous as well as non-cell autonomous manner [141] TAT Modified and...
InvivoGen provides arecombinantmurinized anti-mouse IL-2 monoclonal antibody (mAb) that was previously extracted from hybridoma. It is now expressed and produced in Chinese hamster ovary (CHO) cells, ensuring reliability and lot-to-lot reproducibility. Thereby, common hybridoma-related drawbacks such...
Anti-mGITR-mIgG2a InvivoFit™is arecombinantmurinized anti-mousemonoclonal antibody (mAb) featuring the variable region of the previously described anti-mGITR clone DTA-1 [1]. The rat-derived constant region was replaced by a murine constant region, making the mAb~65% of murine origin. Thi...