Inverse agonists and 5HT7 antagonistThe present invention relates to salt compounds of formula (I) and a pharmaceutically acceptable. These compounds are useful as psychotherapeutic agents.ブライト,ジーン マイケルコフマン,カレン ジェイ.
H3 receptor antagonists/inverse agonists also may be useful for treating cognitive deficits. However, it remains unclear whether these ligands have effects on AHN. The present study aimed to investigate the effects of a 28-day treatment with S 38093, a novel brain- penetrant antagonist/inverse ...
An agonist is a molecule capable of binding to and functionally activating a target. The target is typically a metabotropic and/or ionotropic receptor. An antagonist is a molecule that binds to a target and prevents other molecules (e.g., agonists) from binding. Antagonists have no effect on...
M100,907, a selective 5-HT(2A) antagonist, attenuates dopamine release in the rat medial prefrontal cortex. Brain Res 888: 51–59. Article CAS Google Scholar Pessia M, Jiang ZG, North RA, Johnson SW (1994). Actions of 5-hydroxytryptamine on ventral tegmental area neurons of the rat in...
As an alternative explanation, we considered whether the epitope might have a potential impact on the agonism and performed a competition assay with the different agonists. All antibodies totally competed the FasL:Fas interaction with similar IC50 values, suggesting that the antibodies could be ...
In addition, in the present application, pharmaceutical compositions containing the compounds, and also provides methods for their use. None [Selection Figure]ミルアン クフイトイルシャロン アール. エンゲルクン ケビン ファング
In addition, in the present application, a pharmaceutical formulation comprising a compound, and it also provides methods for their use. None [Selection Figure]ミルアン クフイトイルシャロン アール. エンゲルクン ケビン ファングケルリ エル. スペアル...
;These compounds are useful as psychotherapeutic agents.doi:DE60023492 T2Carsten BehrensThoger Inge CHRISTENSENTibor János KODRAJesper LauAnthony LingFrederik Behrend LUNDTPeter MadsenBruno Michael PLEWEChristian SamsGrove Ulla SIDELMANNDE
Constitutive activity and inverse agonists of G protein-coupled receptors: a current perspective. Mol Pharmacol 2003; 64: 1271–1276. 9 Miura S, Fujino M, Hanzawa H, Kiya Y, Imaizumi S, Matsuo Y, Tomita S, Uehara Y, Karnik SS, Yanagisawa H, Koike H, Komuro I, Saku K. Molecular ...
TRIPLE COMBINATION OF HISTAMINE-3 RECEPTOR INVERSE AGONISTS, ACETYLCHOLINESTERASE INHIBITORS AND NMDA RECEPTOR ANTAGONISTThe present invention relates to a combination of histamine-3 receptor inverse agonist, acetylcholinesterase inhibitor and NMDA receptor antagonist. Also, the present invention provides ...