Grade 3 tumours with either no associated DCIS or DCIS only within the invasive component were significantly larger in size than tumours with surrounding DCIS (P < 0.02) and were less likely to be under or equal to 10 mm in size (0% or 13% vs 30% respectively, P < 0.02). Tumours ...
DCIS is also called intraductal carcinoma orstage 0 breast cancer. DCIS is a non-invasive or pre-invasive breast cancer. This means the cells that line the ducts have changed to cancer cells but they have not spread through the walls of the ducts into the nearby breast tissue. Is ductal c...
Psoriasin (S100A7) is a calcium-binding protein that has shown to be highly expressed in high-grade ductal carcinoma in situ (DCIS) and a subset of invasiv... A Sneh,YS Deol,A Ganju,... - 《Breast Cancer Research & Treatment》 被引量: 38发表: 2013年 加载更多来源...
, 1995). It has been proposed that detecting in situ cancer, particularly high-grade DCIS, would prevent the development of high-grade invasive cancer (Lampejo et al., 1994; Evans et al., 1997, 2001). It is well recognised that many low-grade, special invasive cancers are identified at...
Invasive cancerdeveloped among women with DCIS of all nuclear grades, including 2 with low, 2 with intermediate, and 2 with high nuclear grade lesions. Invasive cancercells traverse these barriers by forming invadopodia; the latter are F-actin-rich protrusions that localize matrix-degrading activity...
The tumours comprised 16 preinvasive cases of ductal carcinoma in situ (DCIS) and 59 mammographically detected early invasive carcinomas. Loss of heterozygosity (LOH) was detected at all four loci and in all types and grade of disease. The frequency of LOH ranged from 23% to 50% depending ...
Pathology: Neoplastic cells are arranged in sheets or nest, and contain clear cytoplasm. GRC usually present withDCISof a solid, clear cell type. • Staging and grading: GRC present with numerous mitoses, and are typically grade 3. Up to 20% of axillary dissections have shown detectablemetas...
In the pure DCIS group, the median DCIS size was 7 cm (range, 5 to 13 cm). The DCIS lesions of both groups were graded as grade 2 or grade 3. On the basis of immunohistochemical subtyping, nine matched pairs were categorized as luminal A subtype and three matched pairs as luminal B...
This in turn has led to proposals that DCIS could be managed by active surveillance instead of immediate treatment with surgery. But a new analysis shows that any diagnosis of DCIS, even when low or intermediate grade, is associated with an increased risk for invasive breast cancer (IBC) and...
The evaluation of molecular markers is performed under the light of their potential usefulness in treatment decisions presenting in the common clinical practice.ADH represents a proliferative lesion that fulfils some, but not all the criteria for a diagnosis of low-grade, non-comedo type DCIS [2,...