The important thing to note in the above is the phrase, ‘As determined by Linden at its sole discretion’. The generally accepted translation of this is, ‘Screw the law, if we do not like it, it is wrong.’ But there is also direct coverage in this sub-article of invasion of priv...
One identified effector, rhoptry protein 1 (ROP1), accumulates in the terminal web of enterocytes through direct interaction with the host protein LIM domain only 7 (LMO7) an organizer of epithelial cell polarity and cell-cell adhesion. Genetic ablation of LMO7 or ROP1 in mice or parasites,...
11,12,13 Integrin/FAK signaling mediates the internalization of microbial pathogens into host cells.9 FAK is a nonreceptor tyrosine kinase that serves as a regulatory center for many signaling pathways,14 and it integrates extracellular signals, such as integrins and mechanical pulling.15,16 The C...
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Traction force microscopy (TFM) is an important family of techniques used to measure and study the role of cellular traction forces (CTFs) associated with many biological processes. However, current standard TFM methods rely on imaging techniques that do
University of Michigan School of Dentistry. Perineural invasion is an aggressive phenotype for head and neck squamous cell carcinomas and other tumors. The chick chorioallantoic membrane model has been used for studying angiogenesis, cancer invasion, an
In pancreatic ductal adenocarcinoma (PDAC), differentiation of pancreatic stellate cells (PSCs) into myofibroblast-like cancer-associated fibroblasts (CAFs) can both promote and suppress tumor progression. Here, we show that the Rho effector protein kinase N2 (PKN2) is critical for PSC myofibroblast...
Radical hysterectomy is a recommended treatment for early-stage cervical cancer. However, the procedure is associated with significant morbidities resulting from the removal of the parametrium. Parametrial cancer invasion (PMI) is found in a minority of