恒定自然杀伤T细胞(Invariant natural killer T cells, iNKT cells)是一种先天样CD1d限制性T细胞,表达恒定T细胞受体(iTCR),在胸腺中经历了一种独特的分化程序,获得了NK样特性,包括具有强大的细胞毒性,可快速分泌细胞因子,可有效转运到组织中等。与NK细胞不同的是,NKT细胞的靶点识别受到CD1d限制(NKT细胞与由CD1d递呈...
Invariant Natural killer T cell (iNKT cells) are a subset of T cells, which are narrowly defined as a T cell lineage expressing a semi-invariant CD1d-restricted T cell Receptors (TCRs) composed by Vα24-Jα18/Vβ11 in human, and Vα14-Jα18/Vβ8,Vβ7, and Vβ2 in mouse. ...
Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate and adaptive immunity. They are activated by conserved bacterial ligands derived from vitamin B biosynthesis and have important roles in defence against bacteri
Invariant natural killer T cells developing in the human fetus accumulate and mature in the small intestine. Mucosal Immunol 2014 Sep;7(5):1233-1243.Loh L, Ivarsson MA, Michaelsson J, Sandberg JK, Nixon DF. Invariant natural killer T cells developing in the human fetus accumulate and mature...
5Mucosal-associated invariant T cells (MAIT) Mucosal-associated invariant T (MAIT) cells are a type ofT cellthat acts as a bridge between the adaptive and innatearmsof theimmune system. They make about 1–10% of total circulatingT cellsin the blood and thebulkof innate-like lymphocytes in ...
Double- positive thymocytes select mucosal-associated invariant T cells. J Immunol (2013) 191(12):6002-9. doi:10.4049/jimmunol.1301212Seach N, Guerri L, Le Bourhis L, et al. Double positive thymocytes select mucosal-associated invariant T cells. J Immunol 2013; 191: 6002-6009....
T cells defined by their Vγ usage22,23, with each wave associated with an effector function and anatomic location24. The first such wave, peaks around embryonic day 14 (E14) and comprises Vγ3+dendritic epidermal T cells (DETCs), which produce interferon-γ (IFNγ) and home to the ...
SCI-20Natural killer T (NKT) cells are distinct innate lymphocytes that recognize lipid ligands in the context of nonclassical MHC molecules called CD1d. NKT cells have been broadly classified into two major types based on their T-cell receptors (TCRs). One group, termed type I invariant, or...
cells express T cell receptors that are generated by somatic DNA rearrangement, these receptors are semi-invariant and interact with a limited set of lipid and glycolipid antigens, thus resembling the pattern-recognition receptors of the innate immune system. Functionally, iNKT cells most closely ...
Invariant natural killer T (iNKT) cells are a specialised subset of T cells that are restricted to the MHC class I like molecule, CD1d. The ligands for iNKT cells are lipids, with the canonical superagonist being -galactosylceramide, a non-mammalian glycosphingolipid. Trafficking of CD1d ...