Intraperitoneal Route of Drug Administration: Should it Be Used in Experimental Animal Studies?Abdullah Al ShoyaibSabrina ArchieVardan T Karamyan
The intraperitoneal (IP) route of administration generally offers the second most rapid absorption of a test article among the parenteral routes, with systemic availability second only to intravenous injection. Rapid absorption is conferred by the large surface area of the lining of the peritoneal cavi...
Intraperitoneal route of drug administration: should it be used in experimental animal studies? Pharm. Res., 37 (1) (2019), p. 12 Google Scholar [21] T. Niendorf, A. Pohlmann, K. Arakelyan, B. Flemming, K. Cantow, J. Hentschel, D. Grosenick, M. Ladwig, H. Reimann, S. Klix,...
This study concluded that the intraperitoneal route of drug administration was associated with longer survival and less toxicity. Further studies should explore the use of intraperitoneal cisplatin and intraperitoneal paclitaxel in patients without residual disease. In the second-line setting the responses...
The optimum route of administration is an importance clinical issue not only for chemical drug, but also for stem cytotherapy. The accessibility of the therapeutic cells to their expectable target site is strongly dependent on the route of administration used. Therefore, the MSCs delivery should be...
In veterinary medicine, the intraperitoneal injection of a lethal dose of pentobarbital is quite commonly performed to euthanise small animals. Intraperitoneal injection is rare as route of administration in humans. 展开 关键词: Suicide Pentobarbital Zolpidem Intraperitoneal injection Postmortem redistribution...
Intraperitoneal DIMATE appeared to be an efficient drug in the prevention or treatment of peritoneal carcinomatosis when combined with cytoreductive surgery or when it was given by intraperitoneal route, before the development of macroscopic peritoneal carcinomatosis. It appears to be a promising ...
route. I.c.v. administration of CGP 35348 (5 and 10 μg) significantly decreased cumulative food intake food intake in rats that had been fasted for 22 h. By contrast, i.c.v. administration of CGP 35348 (10 μg) had no effect on water intake in 16-h water-deprived rats. The ...
By the 1970s, the IP route for drug administration had become the focus of pharmacologic and clinical studies at the National Cancer Institute (NCI), National Institutes of Health (NIH). With Vincent T DeVita Jr, assuming the Directorship of the Division of Cancer Treatment in 1974 to succeed...
IP route promotes more MSCs migration to inflamed colon The number of therapeutic cells that can migrate and colonize at the injury site is a decisive prerequisite for the success of cytotherapy. In order to compare the difference of MSCs colonization among the three delivery routes, a nontoxic ...