This review describes a set of intraocular nano/micro drug delivery systems involved in glaucoma treatment. Particularly, it investigates the structures, properties, and preclinical evidence supporting the use of these systems in glaucoma, followed by discussing the route of administration, the design ...
where Po is the IOP in millimeters of mercury (mmHg), F the rate of aqueous humour formation in microliters per minute (μL/min), U the resorption of aqueous humour through the uveoscleral route (in μL/min), C is the facility of outflow in microliters per minute per millimeter of...
Its onset of action happens in 10 to 15 minutes if given orally and 2 minutes if given by intravenous route.146, 173 It can also provide a relatively safe and well-tolerated method for sedation and subsequent IOP measurements. Studies have suggested that intravenous or oral midazolam does not...
In 89 (82%) of 109 UG eyes and 38 (90%) of 42 SG eyes, steroid therapies had been prescribed prior to ripasudil treatment. The detailed route of steroid administration in UG and SG patients are shown in Supplementary Table 1. Table 2 Characteristics of UG patients. Full size table ...
Conclusion: We have established a Doxycycline-terminable intraocular drug delivery device with good biocompatibility and stability. Successful and complete termination of the device is achieved with 72 hours of Doxycycline administration through oral route. No adverse effect on the retinal anatomy or ...
condition, and the route of administration. Additionally, the formulations may be designed to delay release of the active compound over a given period of time, or to carefully control the amount of drug released at a given time during the course of therapy....
(such as a composition within the scope of the present invention into an anterior sub-tenon because of the widely held belief they have that any polymer remnant will remain visible long after injection, thereby providing a cosmetic deterrent to treatment by such an administration route. Contrary ...
as approved by the FDA for the desired route of administration. These agents may be present in amounts sufficient to maintain a pH of the system of between 2 to 9 and preferably 4 to 8. As such the buffering agent may be as much as 5% on a weight to weight basis of the total comp...
Alternative routes, such as the intravitreal and periocular routes, can provide higher local levels of therapeutics to the retina [8]. The intravitreal route can provide significantly effective drug concentration at retina in comparison with periocular route. However, when small drug molecules are ...
The appropriate route for synthesis of a given polymer-drug conjugate can be determined in view of a number of factors, such as the structure of the polymer-drug conjugate, the identity of the polymers which make up the conjugate, the identity of the active agent, as well as the structure...