Retinoblastoma is one of the most severe ocular diseases, of which current chemotherapy is limited to the repetitive intravitreal injections of chemotherapeutics. Systemic drug administration is a less invasive
Development of NDDS and their application through ocular route has certainly provided an edge to treat DR over existing therapies such as anti-VEGF administration but their success rate is quite low. Moreover, most of them have proved to be effective only in animal models. In addition, extent ...
Group 3: IM route of chitosan bacterin followed by IM route of chitosan bacterin; group 4: commercial bacterin via IM route followed by chitosan bacterin via IO route; group 5: commercial bacterin via IM route followed by commercial bacterin via IM route; group 6: chitosan bacterin via ...
where Po is the IOP in millimeters of mercury (mmHg), F the rate of aqueous humour formation in microliters per minute (μL/min), U the resorption of aqueous humour through the uveoscleral route (in μL/min), C is the facility of outflow in microliters per minute per millimeter of...
Topical administration of IOP-lowering eye drops is a relatively non-invasive and simple route for drug delivery, which is the current gold standard for treatment [25,26]. However, the efficacy of treatment is undermined by patients’ inadequate adherence to medication regimens and limited bioavailab...
12 Dovepress Table 2 Alternate Delivery Routes Route Options Brand Name – Stage (P/C/A) Active Ingredient Extra-ocular Surface implants Bimatoprost ring - C Bimatoprost Topical Ophthalmic Drug Delivery Device (TODDD) - C Drug-eluting contact lenses - P Can hold a number of agents: Timolol,...
such as their baseline characteristics (register number/trial name, year of publication, country or countries, funding, duration), population details (disease, sample size by number of eyes, patient demographics), intervention description (route of administration, dose), and outcome measures (IOP). ...
Conclusion: We have established a Doxycycline-terminable intraocular drug delivery device with good biocompatibility and stability. Successful and complete termination of the device is achieved with 72 hours of Doxycycline administration through oral route. No adverse effect on the retinal anatomy or ...
polyvinyl alcohol and phenylethyl alcohol. Examples of buffering agents that may be employed include, but are not limited to, sodium carbonate, sodium borate, sodium phosphate, sodium acetate, sodium bicarbonate, and the like, as approved by the FDA for the desired route of administration. Electrol...
polyvinyl alcohol and phenylethyl alcohol. Examples of buffering agents that may be employed include, but are not limited to, sodium carbonate, sodium borate, sodium phosphate, sodium acetate, sodium bicarbonate, and the like, as approved by the FDA for the desired route of administration. Electrol...