Calcium-sensing receptor (CaSR) belongs to class-C of the largest cell surface receptor family, the G-protein-coupled-receptors (GPCR’s), which are targets to over 34% of the Food and Drug Administration (FDA) approved drugs in the United States1. CaSR helps maintains a tight systemic C...
The Siva protein is a novel intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. In addition to its positive signaling function in the antigen presentation process, CD4 acts as the primary receptor for HIV-1 . Contact between CD4 and th....
Once translated, these inhibitors inhibit the NF𝜅κB signaling pathway. In contrast, the translated TNF𝛼α is secreted to the extracellular medium, and some of the secreted TNF𝛼α proteins will bind with TNF𝛼α receptor (TNFR) on the cellular membrane to initiate the TNF𝛼α-...
Figure 5.Multiprotein complex by SEC-MAP approach. Analysis of chosen multicomplexes involved in several cell signaling processes. (A): Proteins related to apoptosis inhibition. (B): Protein related to STING signaling. (C): Proteins related to B-cell receptor signaling in membrane and organelle ...
The present invention provides methods and compositions for modulating the phosphorylation of DARPP-32 in a serotonergic receptor intracellular signaling pathway. The invention provides methods and compositions for modulating the activities of DARPP-32, casein kinase 1 (CK1), cyclin-dependent kinase 5 (...
The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. Primarni signalni mehanizam GALR2 receptora je put fosfolipaze C/protein...
This response did not appear to be mediated by protein kinase C because it was unaffected by polymyxin B. Finally, superoxide generation was investigated. It is affected by, but not soley controlled by, either antiport or protein kinase C activity. 展开全部 机器翻译 ...
Cannabinoid receptor IIHigh mobility group box 1AutophagyMacrophagesHigh mobility group box 1 (HMGB1) is a late phase inflammatory mediator in many inflammatory diseases. Extracellular HMGB1 could bind to many membrane receptors to activate downstream signaling molecules and promote inflammation resulting in...
The androgen receptor (AR) pathway plays a central role in prostate cancer (PCa) growth and progression and is a validated therapeutic target. In response to ligand binding AR translocates to the nucleus, though the molecular mec...
Naseer MI, Lee HY, Ullah N, Ullah I, Park MS, Kim SH, Kim MO (2010) Ethanol and PTZ effects on siRNA mediated GABAB1 receptor: down regulation of intracellular signaling pathway in prenatal rat cortical and hippocampal neurons. Synapse 64:181- 190...