Development of faecal flora was studied in seven very low birth weight (VLBW) infants, who were fed on human milk and whose birth weights ranged from 810–1350 g. The intestine of the VLBW infants was first colonised by enterobacteria and streptococci, as it was in full-term infants. VLBW...
Bedside peritoneal drainage in very low birth weight infants Background: Bedside peritoneal drainage is emerging as a useful therapy for premature infants with intestinal perforation in the newborn period. Some autho... HGS Noble,M Driessnack - 《American Journal of Surgery》 被引量: 32发表: 20...
The current studies showed that dose regimen matters when testing intestinal permeability by FD-4 in a DIO model. We showed that the readout is biased by significant differences in dose when comparing lean and obese mice after dosing according to body weight. This can, however, be avoided by ...
In ob/ob mice, where increased body weight is primarily due to increased fat accumulation, the length of the small intestines correlated with the body weight (Fig. 1e), while being independent of the lean (muscle) mass (Fig. 1f). Analysis of faeces by bomb calorimetry revealed increased ...
A multicompartment model has been developed for the mathematical analysis of the passage of low-molecular-weight molecules from the intestine to the urine in man, with special reference to the permeation of different-size polyethyleneglycols (PEG 400). The influence of intestinal properties such as...
(Fig.1A). After a successive selection for five generations, we collected 11 and 9 intestinal tissue samples, as well as their intestinal content from the resistant and susceptible families, respectively (Fig.1and Supplementary Table1). The body weight (BW) and length (BL) were measured for ...
Intestinal permeability was assessed as described previously [79]. Briefly, mice were gavaged with FITC-dextran (Catalog# 46,944, MW:4000; Sigma, St. Louis, MO, USA) at a dose of 60 mg/100 g body weight at a concentration of 120 mg/mL. Four hours later, after euthanasia, blood was...
However, the relative weight was significantly lightest and the caecal length was significantly shortest ( P 0.05) in the pectin group. 5. Activities of amylase and cellulose hydrolases of the caecal contents were also highest in the pectin group. 6. From SEM micrographs, no morphological ...
Animals treated with AAVrh10-IL-10 had lower disease activity index scores, higher colon weight-to-length ratios, and lower microscopic inflammation scores. This study identifies novel AAV pseudotypes with small intestine and colon tropism and sustained transgene expression capable of modulating ...
We here show that an increase in SIRT3 expression and function in the enterocytes had no impact on body weight, body composition, or fat distribution, and iSIRT3 mice on HFD developed DIO similar to S3fl mice. Both S3fl and iSIRT3 mice also showed increased jejunal villi length and had...