(1992) Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11p15.5. Biochem. Biophys. Res. Commun. 183, 821-828Xu, G., Huan, L., Khatri, U.S., McCool, D., Wang, D., Jones, Forstner, G. and...
Mucins are highly O-glycosylated molecules that have gel-like properties. The mucin family consists of transmembrane mucins and gel-forming mucins. The transmembrane mucins cover the apical surfaces of the enterocytes and form the glycocalyx. The gel-forming mucins are secreted from goblet cells as ...
The inflammasome is a cytosolic multi-protein innate immune rheostat, sensing a variety of endogenous and environmental stimuli, and regulating homeostasis or damage control. In the gastrointestinal tract, inflammasomes orchestrate immune tolerance to mi
Mucins are highlyO-glycosylated molecules that have gel-like properties. The mucin family consists of transmembrane mucins and gel-forming mucins. The transmembrane mucins cover the apical surfaces of the enterocytes and form the glycocalyx. The gel-forming mucins are secreted from goblet cells as la...
Furthermore, SPI attenuated intestinal mucin production, as demonstrated by the decreased numbers of intestinal goblet cells and the reduced relative expression levels of mucin 1 (Muc1), mucin 2 (Muc2), trefoil factor 3 (Tff3), glucose-regulated protein 94 (Grp94), and anterior gradient homolog...
A crucial part of the gut barrier is the mucus layer, a cross-linked gel on top of the intestinal epithelium that consists predominantly of the mucin glycoprotein MUC2. However, whether the mucin layer actively regulates intestinal immune cell responses is not clear. Because recent evidence ...
Intestinal mucin 2 (MUC2) encodes a heavily glycosylated, gel-forming mucin, which creates an important protective mucosal layer along the gastrointestinal tract in humans and other species. This first line of defense guards against attacks from microorg
Johansson ME, Phillipson M, Petersson J, Velcich A, Holm L, Hansson GC: The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A. 2008, 105 (39): 15064-15069. 10.1073/pnas.0803124105. Article CAS PubMed PubMed Central Google ...
1c). We then conducted immunofluorescence staining in mouse tissue and organoids, and found that the Rnase4 protein was present in the intestinal epithelium, with a notable enrichment in secretory, granule-like structures of goblet and Paneth cells (Fig. 1d, e). Furthermore, we detected the ...
beneficial and detrimental roles in gut homoeostasis and inflammation6,7,8. Mucus-adherent T4 phage can express Immunoglobulin (Ig)-like protein domains on their capsid which bind to mucin glycoproteins at the intestinal mucus layer, therefore defending against infection of the intestinal epithelium ...