rats that received ketamine(P=0.017).BER was not statistically different between groups.CONCLUSION:Our results show that ketamine anesthesia is associated with diminished intestinal iniury and abolishes the intestinal transit delay induced by ischemia/reperfusion.(C)2008 The WJG Press.All rights ...
42 Thus, the lower level of LCN2 in the ethanol-fed SIRT1iKO mice might be a response for the iron deprivation, attenuated neutrophilic information, and diminished ferropotic liver injury. Further studies are needed to investigate whether and how the LCN2–SAA1 signaling is involved in ...
demonstrated to have an important impact in tissue injury under some pathological conditions, such as ischemia– reperfusion (I/R) induced injury in intestines, brain, myo- cardium and liver.17,18 Many evidence reveals that apoptosis is a major mode of cell death caused by I/R in these ...
Ischemia is often a concern in the early postoperative period when the ileostomy can appear edematous and slightly cyanotic. This appearance will generally improve spontaneously. However, if the blood supply was compromised during construction of the stoma, then progression to necrosis, retraction, and...
MA regulates macrophage polarization and promotes intestinal recovery from ischemia–reperfusion (I/R) injury through a suppressor of cytokine signaling 2-dependent mechanism, positively impacting intestinal injury repair [38]. In addition, we observed that blood in the stool did not improve at the ...
Discussion Cardiac dysfunction can lead to intestinal ischemia and hypoxia, which in turn increases intestinal permeability and circulating inflammatory factors [7, 10]. Patients with HF exhibit an abnormally high abundance of pathogenic bacteria in their intestines, resulting in a 210% increase in ...
The precise relationship between LCN2 and gastrointestinal diseases remains incompletely understood, particularly concerning its involvement in complex conditions such as intestinal fistula, intestinal ischemia/reperfusion injury, and other forms of intestinal damage. A comprehensive exploration of the mechanisms...
such as ischemia–reperfusion (I/R) induced injury in intestines, brain, myocardium and liver.17,18Many evidence reveals that apoptosis is a major mode of cell death caused by I/R in these tissues. The small intestine is prone to be subjected to ischemic-induced apoptosis because of the pri...
Ischemia-reperfusion injury (IRI): In AP, release of proinflammatory cytokines such as TNF-α could lead to IRI of gut mucosa and disturb the intestinal microcirculation [17]. One of the major causes of impaired intestinal microcirculation is the destruction of glycocalyx [18]. In an animal ...
The intestinal epithelium sits at the interface between an organism and its luminal environment, prone to oxidative damage induced by luminal oxidants. Mucosal oxidative injury contributes to the development of degenerative pathologies of the intestine, such as inflammation, ischemia, and cancer [42, 43...