rats that received ketamine(P=0.017).BER was not statistically different between groups.CONCLUSION:Our results show that ketamine anesthesia is associated with diminished intestinal iniury and abolishes the intestinal transit delay induced by ischemia/reperfusion.(C)2008 The WJG Press.All rights ...
demonstrated to have an important impact in tissue injury under some pathological conditions, such as ischemia– reperfusion (I/R) induced injury in intestines, brain, myo- cardium and liver.17,18 Many evidence reveals that apoptosis is a major mode of cell death caused by I/R in these ...
The intestinal epithelium sits at the interface between an organism and its luminal environment, prone to oxidative damage induced by luminal oxidants. Mucosal oxidative injury contributes to the development of degenerative pathologies of the intestine, such as inflammation, ischemia, and cancer [42, 43...
We designed the current study to investigate the patho- physiology of intestinal ischemia and injury caused by bacterial endotoxin (LPS) and hypoxia and to evaluate the role of PAF, acetylhydrolase, and TNF in this new experimental model of intestinal necrosis. NEC is a common gastrointestinal ...
Cardiac dysfunction can lead to intestinal ischemia and hypoxia, which in turn increases intestinal permeability and circulating inflammatory factors [7, 10]. Patients with HF exhibit an abnormally high abundance of pathogenic bacteria in their intestines, resulting in a 210% increase in colonic permea...
Establishing a differential diagnosis is important, especially when the condition causing renal failure can be controlled and further renal damage can be prevented, such as with vasculitis, drug-induced nephropathy, autoimmune disease, renal ischemia, and infectious diseases. Given the high prevalence of...
Enteroendocrine L cells secrete the hormone GLP-1, which was initially classified as a glucoregulatory hormone but also demonstrates anti-inflammatory properties and supports mucosal integrity [74]. In Lebrun’s study, it was observed that circulating GLP-1 levels sharply increased during ischemia/rep...
Y4 receptor agonists which are selective of the Y4 receptor over the Y1 and Y2 receptors, are useful in the prevention and/or treatment of damage to bowel function caused by radiation therapy, radiation exposure, cytotoxic chemotherapy, inflammation or ischemia-reperfusion of intestinal mucosa.收藏...
Ischemia-reperfusioninjury(IRI): In AP, release of proinflammatory cytokines such as TNF-α could lead toIRIof gutmucosaand disturb the intestinalmicrocirculation[17]. One of the major causes of impaired intestinal microcirculation is the destruction ofglycocalyx[18]. In an animal model, alterati...
Intestinal ischemia/reperfusion (Is/Re) is a known critical condition that occurs intrauma, intestinal obstruction/transplantation, andseptic shock[1]. During intestinal Is/Re, multiple outcomes mustered to disorganize the equipoise between the protective and the destructive episodes. Oxidative stress (...