Interrupted reactions reroute established processes to new and often unanticipated end points. Of particular interest are the cases in which a known reactive intermediate takes on a new reaction pathway, either because this pathway is lower in energy or because the conventional pathway is no longer ...
Radical Reduction: Why Organometal-hydride Chain Reactions Stop and How to Make Them Go? Nonidealkinetic chain analysis was used to examine the kineticlimitations of free-radical synthesis. Homolytic aromatic substitution(HAS: ArH + R•→ ArR + H•) occurs in a chain-terminating side reaction...
Domino or tandem reactions are receiving a great deal of attention within the field of organic synthesis. The ability to form a number of new bonds in a single step often leads to a great increase in molecular complexity, which can decrease the number of chemical steps overall within a ...
Suzuki-Miyaura cross-coupling reactions have proven to be an indispensable method for chemical synthesis. Significant advances have been achieved to couple a wide-range of cross partners under mild conditions. Typically these reactions are catalyzed by Pd- and Ni-complexes. Herein, a Cu-catalyzed ...
Radical Arene Addition vs Radical Reduction: Why Organometal Hydride Chain Reactions Stop and How To Make Them Go Nonideal kinetic chain analysis was used to examine the kinetic limitations of free-radical synthesis. Homolytic aromatic substitution (HAS: ArH + R center... VW Bowry,C Chatgilialog...
CHEMICAL reactionsPYRROLESCHEMICAL synthesisDIHYDROFURANS synthesisAMMONIAALCOHOLReaction of 3-aryl-2-chloropropanal with 1-arylsulfonylpropan-2-ones in aqueous ammonia and alcohol under the conditions of Hantzsch pyrrole synthesis led to the selective formation of the products of interrupted Feist-Benary ...
a three-component reaction is also achieved involving O-/N-propargyl benzyl thiosulfonates,benzyl bromide,and sodium azide to deliver fused-triazoles in 61-74% yields.From a synthetic point of view,the present protocol has been demonstrated at gram-scale reactions.A plausible mechanism is also ...