First, because the mask from the first optimization step is sparse and near-binary, the grid-search area can be limited to small regions around unique values found in m1:T∗. Second, the grid search can also be limited to optimizing backwards through time, applying the same threshold ...
using known biological signaling pathways, the expression profiles of cancer cell lines, drug - protein interactions, and drug sensitivity datasets. The pathway maps were obtained from the KEGG database. DK was integrated into the DNN model via the layer of...