NLRP3 pathwayOral squamous cell carcinomaSTAT3Sox4Background:Interleukin-6 (IL-6) has been reported to be critical in oral squamous cell carcinoma (OSCC). However, the set of pathways that IL-6 might activate in OSCC are not fully understood. Methods:IL-6 and Sox4 expressions were first ...
In fact, downregulation of CAV1 expression resulted in the activation of AKT signaling, promoting cell invasion, and growth transformation induced by KSHV. Finally, genetic deletion of vIL-6 from the KSHV genome abolished KSHV-induced cellular transformation and impaired angiogenesis. Our results ...
2 cells, as well as T helper cells that produce IL-17, to secrete IL-10. This effect was dependent on the transcription factors STAT1 and STAT3 for IL-27 and on STAT3 for IL-6. Our studies identify a previously unknown pathway that allows the immune system to temper inflammatory ...
Cross-talk between PRKCZ and the IL4/STAT6 signaling pathway has been reported during T cell–mediated hepatitis and lung airway inflammation, whereby decreased STAT6 phosphorylation was observed in both livers of PKCZ−/− mice after concanavalin A-induced hepatitis and in PKCZ−/− ...
FANG D, KONG LY, CAI J, et al. Interleukin-6-mediated functional upregulation of TRPV1 receptors in dorsal root ganglion neurons through the activation of JAK/PI3K signaling pathway : roles in the development of bone cancer pain in a rat model [J]. Pain, 2015, 156(6): 1124-1144....
In this study, we demonstrate the novel binding site, i.e., the interface of IL-6 and IL-6R伪 of the IL-6/STAT3 signaling pathway of cancer progression. Ten potent anticancer phytocompounds were analyzed for their binding with IL-6/IL-6R伪 complex using molecular docking and molecular ...
Conclusions rhIL-6 had obvious antitumor effects on mouse bladder carcinoma in vivo, and the Fas signaling pathway might play an important role in rhIL-6-induced bladder carcinoma cell apoptosis.doi:10.1007/s00280-010-1336-7Chuan-gang Li
Thus, our aims were to determine if LPS stimulates cholangiocyte proliferation by IL-6-dependent signaling pathways. H69 cells derived from normal human intrahepatic cholangiocytes proliferated in response to LPS. Cholangiocytes responded to LPS (and other inflammatory cytokines such as tumor ...
Interleukin (IL)-6-mediated signaling attenuates the anti-myeloma activity of glucocorticoids (GCs). We therefore sought to evaluate whether CNTO 328, an anti-IL-6 monoclonal antibody in clinical development, could enhance the apoptotic activity of dexamethasone (dex) in pre-clinical models of ...
Signaling of IL-6 is transduced by activation of STAT3 (signal transducer and activator of transcription 3), which rapidly induces the production of acute-phase proteins such as haptoglobin and fibrinogen. Another target of the IL-6/STAT3 signal transduction pathway is the microRNA cluster miR-17...