Pietruczuk A, Swierzbinska R, Pancewicz S, Pietruczuk M, Hermanowska-Szpakowicz T. Serum levels of interleukin-18 (IL-18), interleukin-1ß (IL-1ß), its soluble receptor sIL-1RII and C-reactive protein (CRP) in patients with Lyme arthritis. Infection 2006;34:158-62....
A proinflammatory cytokine interleukin 18 (IL-18) and its receptor are prominently expressed in atherosclerotic plaques. In addition, circulating IL-18 levels were reported to be high in ACS. In this study, we have examined if IL-18 can stimulate shedding of LOX-1 and subsequent release of ...
Objective:To study the changes of serum interleukin-18(IL-18)level and placentga growth factor(PLGF)and its clinical significance in patients with hypertensive disorder complicating pregnancy.Methods:Serum concentrations of interleukin-18 and Human soluble vascular endomelial growth factor receptor 1(sFl...
Noun1.interleukin- any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system lymphokine- a cytokine secreted by helper T cells in response to stimulation by antigens and that acts on other cells of the immune system (as by ...
Although interleukin-18 is structurally homologous to IL-1 and its receptor belongs to the IL-1R/Toll-like receptor (TLR) superfamily, its function is quit... K Nakanishi,T Yoshimoto,H Tsutsui,... - 《Annual Review of Immunology》 被引量: 2518发表: 2001年 Interleukin-18 Is a Strong Pred...
we present a crystal structure of human IL-18 bound to the two receptor extracellular domains. Generally, the receptors’ recognition mode for IL-18 is similar to IL-1β; however, certain notable differences were observed. The architecture of the IL-18 receptor second domain (D2) is unique ...
Methods We investigated the clinical course, pulmonary involvement, and serum levels of IL-18, IFN-γ, IL-12p40, and soluble IL-2 receptor (sIL-2R) in 21 patients with acute-stage MP and in 21 age- and sex-matched control subjects. Results Significantly (p < 0.001) increased serum IL...
Directly targeting the IL-18R receptor, e.g. via antibody or specific antagonist, is also of potential interest, although shared utilisation with other IL-1 cytokines, e.g. IL-1F7, may reduce the specificity of such an approach [26]. Small molecule approaches include inhibitors of caspase-1...
Human immunodeficiency virus type 1 (HIV-1) Nef protein causes the loss of cell surface CD4 and interleukin-2 (IL-2) receptor (Tac) from peripheral blood m... A Greenway,A Azad,D Mcphee - 《Journal of Virology》 被引量: 176发表: 1995年 Human immunodeficiency virus does not induce inter...
Finally, the recent discovery of novel IL-18 receptor subunits in the brain has revealed the complexity of the IL-18 system and may lead to better understanding of both the similarities and opposing actions of IL-1 and IL-18. This review summarizes more than a decade of work aimed at ...