Aim: To report the safety profile of Interleukin-17 (IL-17) inhibitor, namely injection secukinumab in patients of psoriasis vulgaris during COVID-19 pandemic. Materials and Methods: An ambispective interventional study was performed on 23 patients of psoriasis w...
Tissue inhibitor of metalloproteaseInterleukin 17 (IL-17) is a proinflammatory cytokine, produced only by activated lymphocytes, but with a broad cellular host range. The effects of IL-17 on fibroblasts were investigated by analysis of the induction of chemokine and matrix metalloprotease (MMP) mRNA...
Tumor necrosis factor inhibitor (TNFi) has been applied in the treatment of ankylosing spondylitis (AS) for many years but still with an unmed need due to inefficacy or intolerance. Current treatment guideline recommended the use of IL-17 inhibitors over a second TNFi in patients with primary...
HGF/NK4, a four-kringle antagonist of hepatocyte growth factor, is an angiogenesis inhibitor that suppresses tumor growth and metastasis in mice. Cancer Res., 60 (2000), pp. 6737-6743 View in ScopusGoogle Scholar 18 K Ohno-Matsui, I Morita, J Tombran-Tink, et al. Novel mechanism for ...
Bimekizumab: The First Dual Inhibitor of Interleukin (IL)-17A and IL-17F for the Treatment of Psoriatic Disease and Ankylosing SpondylitisPsoriasis is a chronic inflammatory skin disease with significant psychological and physical impact. Over the last few decades, several highly effective target ...
The AKT inhibitor, LY294002, and the knockdown of AKT expression reversed the rIL-17B-induced upregulation of β-catenin and some stemness markers. Together, our results indicate that the IL-17B/IL-17RB signal can promote the growth and migration of tumor cells, and upregulate cell stemness...
Netherton syndrome subtypes share IL-17/IL-36 signature with distinct IFN-α and allergic responses Background:Netherton syndrome (NS) is a rare recessive skin disorder caused by loss-of-function mutations in SPINK5 encoding the protease inhibitor LEKTI (... C Barbieux,MBD Claustres,M Fahrner,...
IL-17 induced MMP7 and EMT in human prostate cancer LNCaP, C4-2B, and PC-3 cell lines, while siRNA knockdown of MMP7 inhibited IL-17-induced EMT. Compound III, a selective MMP7 inhibitor, decreased development of invasive prostate cancer inPtensingle knockout mice. In human normal ...
In a recent issue of The Journal, Pavelka and colleagues reported on a negative study of brodalumab, the interleukin 17 (IL-17) inhibitor, in rheumatoid arthritis (RA). In addition to the authors' conclusion that there is no reason to pursue further evaluation of the molecule, an antibody ...
Furthermore, this enhancing effect of IL-17 on immunosuppression of MSCs was completely reversed by iNOS inhibitor, L-NMMA (Figure 1h), suggesting that iNOS has a crucial role in this action of IL-17. To expand our studies, we compared the function of IL-17 between bone marrow–derived ...