Interleukin (IL-6) Immunotherapydoi:10.1101/CSHPERSPECT.A028456Toshio TanakaMasashi NarazakiTadamitsu KishimotoCold Spring Harb Perspect BiolTanaka, T.; Narazaki, M.; Kishimoto, T. Interleukin (IL-6) Immunotherapy. Cold Spring Harb. Perspect. Biol. 2018, 10. [CrossRef] [PubMed]...
Interleukin 6 (IL-6) is a prototypical cytokine for maintaining homeostasis. When homeostasis is disrupted by infections or tissue injuries, IL-6 is produced immediately and contributes to host defense against such emergent stress through activation of acute-phase and immune responses. However, dysreg...
IL-6 has also been shown to promote angiogenesis via VEGF secretion by human peritoneal mesothelial cells, in the context of trans signalling (i.e., simultaneous exposure to IL-6 and sIL6-Rα) [92], as well as in the context of tumor stromal fibroblast-secreted IL-6 acting in an auto...
(IL-2) levels could be used to predict response to immunotherapy, leading to more personalized treatment options for cancer patients. Interleukin biomarkers could also be used to stratify cancer patients into subgroups based on their likelihood of response to specific therapies, identifying patients ...
Interleukin-1 alpha (IL-1 alpha) is a low-molecular-weight cytokine that regulates proliferation and differentiation of lymphatic and myeloid cells. It als... AR Hanauske,D Degen,MH Marshall,... - 《Journal of Immunotherapy Official Journal of the Society for Biological Therapy》 被引量: 19...
- 《Cancer Immunology Immunotherapy Cii》 被引量: 96发表: 1991年 Effect of IL-18 on the release of IL-6 and its soluble receptors: sIL-6Ralpha and sgp130 by human neutrophils. The biological activities of IL-18 include its ability to induce the production of inflammatory cytokines such as...
Immunotherapeutic implications of IL-6 blockade for cytokine storm. Immunotherapy 2016; 8: 959–970. 51 Chourbaji S, Urani A, Inta I, Sanchis-Segura C, Brandwein C, Zink M et al. IL-6 knock-out mice exhibit resilience to stress-induced development of depression- like behaviors. Neurobiol...
Interleukin 6 (IL-6), a cytokine produced by skeletal cells, stimulates osteoclast recruitment. The IL-6 soluble receptor (sIL-6R) increases IL-6 activity, and IL-6 and sIL-6R levels are increased in conditions of increased bone resorption. We examined the production of IL-6 by primary rat...
RhIL-6 (150 microgram) was administered as a daily subcutaneous injection for 42 consecutive days on an outpatient basis. Forty-nine patients were studied, 12 with and 37 without previous immunotherapy. Forty patients were evaluable for response. A partial remission was noted in two patients, ...
Schoenenberger G.A.: Burn toxins isolated from mouse and human skin. Their characterization and immunotherapy effects. Monogr. Allergy, 9: 72-139, 1975. Kataranovski J., Kucuk J., Colic M., Rapaji C.D., Lific N., Pejnovic N., Dujic A.: Post-traumatic activation of draining lymph...