This paper reports the cloning and sequencing of interleukin (IL)-23 p19 subunit for the first time within a non-mammalian species, the zebrafish ( Danio rerio), which was discovered using a synteny approach. In addition, amino acid sequences were for IL-23 p19 subunits were also predicted...
Interleukin 23 Synonyms IL-23;IL-23A;IL-23p19;p19;SGRF Definition IL-23 is a heterodimeric cytokine which belongs to the IL-12 cytokine family. It is composed of a specific alpha chain, p19 (IL-23A), and a shared beta chain, p40 (IL12β) subunit. The p40 subunit can also dimerize...
Precision of the ELISA Kit for Interleukin 23 Subunit Alpha (IL23a) Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Interleukin 23 Subunit Alpha (IL23a) were tested 20 times on one plate, respectively. ...
IL-23 is a member of IL-12 cytokine family12,13 and consists of IL-23 subunit p19 (IL-23p19) and IL-12 subunit p40 (IL-12p40). The IL-23R and IL-12Rβ1 subunits comprise the IL-23 receptor complex and bind to IL-23p19 and IL-12p40, respectively14. IL-23 is produced prima...
23. While pDC produced both mRNA and protein of the p40 subunit,? thelack of bioactive heterodimeric IL-?23 protein release was related to the fact that in these cells only the p19 mRNA wasexpressed which was not translated into protein. In addition to these differential findings in both ...
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IL-23 is a key cytokine involved in inflammatory diseases as well as cancer and has become a major therapeutic target in the clinics24,25,26,27. It is composed of one α-and one β-subunit, which need to assemble in order for the cytokine to be secreted23. We show that locally ...
has shown positive responses in CD patients resistant to anti-tumor necrosis factor alpha (TNF-α) treatment (Sandborn et al., 2012), and recent data from a Phase 2a study for MEDI2070—a monoclonal antibody against the p19 subunit of IL-23—has shown great promise in treating TNF-α-th...
Interleukin-23 subunit p19 Interleukin-24 Interleukin-25 Interleukin-26 interleukin-27 subunit alpha interleukin-28A interleukin-28B interleukin-28B gene interleukin-28B gene interleukin-28B gene interleukin-28B gene interleukin-28C interleukin-3 interleukin-3 interleukin-3 interleukin-3 Interleukin-3 promote...