at the mar- gins of chronic active MS lesions Cryostat sections of fresh frozen tissue from MS pa- tients (17) were processed for colabeling apoptotic nuclei (brown) and MOG (purple/black), (a and b), human IFNy (d and e), and oil-O-red to identify active phagocytic cells (c)....
Cellular immune responses of schistosomiasis patients are altered by human immunodeficiency virus type 1 coinfection. To test this hypothesis, a comparison was done of proliferation and cytokine production by peripheral blood mononuclear cells from patients with schistosomiasis... PNM Mwinzi,DMS Karanja...
This invention provides crystalline recombinant interferon (rSIFN-co) having (i) the same amino acid sequence as that of human consensus interferon, and (ii) altered three-dimensional structure as compared to IFN-伪2b. The interferon of the present invention exhibits enhanced biological activities. ...
doi:10.1002/(SICI)1097-4644(19960201)60:2<235::AID-JCB8>3.0.COThe specific signal transduction pathway(s) involved in the induction of the expression of the MHC class II molecule, la, on macrophages by interferon- (IFN-) is unclear. In this paper, we assessed the role of several ...
申请(专利权)人: HOFFMANN-LA ROCHE, F. + CO. A.G. 发明人:S Honda,HF Kung,H Sugino 摘要: An intact human immune interferon protein and a method for its extraction and purification is disclosed. This method permits the purification to homogeneity of intact recombinant human immune interferon ...
IFN-α is a Type I interferon which signals through IFNAR receptor complex that consists of IFNAR1 and IFNAR2; it mainly has antiproliferative and antiviral effects. Among the several isoforms, IFN-α2b has been found to be effective in the treatment of melanoma and its use was approved for...
1¿ is hydrogen or the like; R?2¿ is cyano or the like; A is -CO- or the like; W is -CH¿2?- or the like; Q is phenyl or the like; n is 0 to 2; and R?7¿ is hydrogen or the like.Mizuguchi, Kiyoshi c/o . Mochida Pharmaceutical Co....
来自 dbpia.co.kr 喜欢 0 阅读量: 15 作者:박이내,심태선 摘要: Background/Aims: The usefulness of interferon-γ release assays (IGRAs) in monitoring to responses to anti-tuberculosis (TB) treatment is controversial. We compared the results of two IGRAs before and after anti-TB ...
Exposure of macrophages in vivo to both immunomodulators in combination can be effected by using liposomes as carriers. It was observed that administration of MTPPE and IFN- y co-encapsulated in liposomes resulted in a synergistic enhanced antibacterial resistance against L. monocytogenes . Both ...
Syncytium -inducing variants were detected by cocultivation of peripheral blood mononuclear cells with the MT-2 T-cell line. Overall, 16 of 83 (19%) patients underwent a shift to syncytium-inducing phenotype: 11 of 67 during zidovudine treatment, 3 of 10 during zidovudine plus alpha ...