beta-interferon- a form of interferon that is produced by fibroblasts and have antiviral effects; used in the treatment of multiple sclerosis gamma-interferon- a form of interferon that is produced by T cells and macrophages; involved in the activation of phagocytes ...
The aim of this study was to evaluate the therapeutic effects of IFN-beta-1a administration in COVID-19.doi:10.1016/j.intimp.2020.106688Farzaneh Dastan a bSeyed Alireza Nadji cAli Saffaei dMajid Marjani eAfshin Moniri cHamidreza Jamaati b...
别名 Biferonex、HSA-free IFN β-1a、Interferon beta-1a 靶点 IFNAR 作用机制 IFNAR激动剂(干扰素α/β受体复合体激动剂)、免疫调节剂 治疗领域 免疫系统疾病神经系统疾病其他疾病 在研适应症- 非在研适应症 多发性硬化症 原研机构 Rentschler Biotechnologie GmbH 在研机构- 非在研机构 Biopartners GmbHRentschl...
Interferon beta-1b (Betaseron) and interferon beta-1a (Avonex) were originally thought to increase the resistance of tissues, including those of the CNS, against viral infections. There are currently no data to suggest that viral inhibition underlies interferon beta effects onMSin any way.36The...
Pharmacokinetic studies indicate that intramuscular injection is the optimal route of administration for this formulation of interferon-β-1a. In patients with relapsing- remitting multiple sclerosis who participated in a randomised double- blind trial, interferon-β-1a 30µg (6 MIU) administered by ...
(ifn)β-1a has been shown to upregulate cd73, prevent vascular leakage, 6 and inhibit leukocyte recruitment. 7 a pilot open-label nonrandomized phase 1/2 study showed that administration of recombinant human ifn-β-1a was associated with significantly lower 28-day mortality compared with non...
Putative markers of inflammation such as serum beta2-microglobulin and neopterin have been shown to be transiently upregulated following interferon-beta (IFN-beta) administration to multiple sclerosis (MS) patients. However, to date the role of the important inflammatory mediators serum amyloid A prote...
This investigation was repeated after 6-month IFN-beta therapy. Plasma ACTH and cortisol concentrations followed their physiological rhythms, with lower levels in the evening compared to the morning, but raised earlier and stronger in group B after IFN-beta administration. IFN-beta injection in the...
Comparative pharmacokinetics and pharmacodynamics of recombinant human interferon beta-1a after intramuscular and subcutaneous administration To evaluate whether recombinant human interferon-beta-1a significantly affects disease activity as measured by a reduction in the number and volume of Gd e... MC Rogge...
目的:抑郁症与中医百合病有着 密切的关联,肠道异常反应是百合病的病症之一,临床上抑郁症患者常伴有肠易激综合征(IBS)等胃肠道并发症或合并症,脑-肠互动理论揭示了抑郁症多伴有 IBS的原因,但其科学理论尚未阐明.本研究基于脑-肠互动理论初步探讨百合皂苷,知母皂苷,百合知母皂苷对抑郁症伴IBS的治疗作用及其相关机制....