Interferon-alpha-inducible proteins are novel autoantigens in murine lupus. Arthritis Rheum 2004; 50: 3239-3249.Hueber W., Zeng D., Strober S. and Utz P.J. (2004). Interferon-alpha- inducible proteins are novel autoantigens in murine lupus. Arthritis Rheum. 50, 3239-3249....
Viral entry requires co-operative interactions of several host cell factors. Interferon (IFN) and the IFN-stimulated genes (ISGs) play a central role in antiviral responses against hepatitis C virus (HCV) infection. We examined the effect of interferon-α inducible protein 6 (IFI6) against HCV...
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Finally, we show that IFIX mediates HDM2 downregulation in an IFN-inducible system. Together, these results suggest that IFIXalpha1 functions as a tumor suppressor by repressing HDM2 function. 展开 关键词: HEMATOPOIESIS INTERFERON PROTEINS CELL differentiation UBIQUITIN ...
Objective To explore the expression of interferon γ inducible protein 10(IP-10)mRNA in peripheral blood mononuclear cell(PBMC)in children with Kawasaki disease(KD)and its significance. 目的探讨川崎病(KD)患儿外周血单个核细胞(PBMC)中γ干扰素诱导蛋白-10(IP-10) mRNA表达意义。3) Interferon-gamma-...
Interferon-inducible protein IFIXα inhibits cell invasion by upregulating the metastasis suppressor maspin IFIXalpha, a member of the interferon-inducible HIN-200 family, has been identified as a putative tumor suppressor. However, the molecular mechanisms under... H Yamaguchi,Y Ding,JF Lee,... ...
and Type III.Type I IFNinclude alpha (IFNA), beta (IFNB), delta (IFND), epsilon (IFNE), tau (IFNT), and omega (IFNW). TheType II IFNclass is represented by a single member, termed IFN gamma (IFNG), and theType III IFNclass contains at least three members that are known either...
Applicants identified interferon-gamma-inducible protein 16 (IFI16) as an innate immune DNA sensor required to induce the death of human lymphoid CD4 T-cells abortively infected with HIV-1. Provided herein are compositions and methods for identifying inhibitors of (IFI16). IFI16 inhibitors are ...