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To assess if the GReX component could have a different contribution in brain or in blood expression, we estimated the GreX component of the IFN alpha/beta signaling pathway genes in ten different brain areas, and we tested their association with MDD. In the brain, the mean number of genes ...
Three forms of interferon—alpha (α), beta (β), and gamma (γ)—have been recognized. These interferons have been classified into two types: type I includes the alpha and beta forms, and type II consists of the gamma form. This division is based on the type of cell that produces the...
A. et al. Structural basis of a unique interferon-beta signaling axis mediated via the receptor IFNAR1. Nat. Immunol. 14, 901–907 (2013). CAS PubMed Google Scholar Ivashkiv, L. B. & Donlin, L. T. Regulation of type I interferon responses. Nat. Rev. Immunol. 14, 36–49 (2014...
Three cell-signaling molecules—tumor necrosis factor alpha, interleukin 6 and interferon beta—stood out in long COVID patients. Stephani Sutherland, Scientific American, 14 Feb. 2023 UT Southwestern is also studying Synairgen’s interferon beta therapy, an inhaled antiviral protein, through the ACTIV...
Transforming growth factor-beta (TGF-beta) and interferon-gamma (IFN-gamma) exert antagonistic effects on collagen synthesis in human dermal fibroblasts. We have recently shown that Y box-binding protein YB-1 mediates the inhibitory effects of IFN-gamma on alpha2(I) procollagen gene (COL1A2) ...
Differential regulation of corticotropin releasing factor 1alpha receptor endocytosis and trafficking by beta-arrestins and Rab GTPases. The corticotropin releasing factor (CRF) type 1± receptor, a member of the G protein-coupled receptor (GPCR) subfamily B, is involved in the aetiology of ......
Further studies are clearly needed to establish the precise role of IFN-α in lupus, and then whether it can be specifically targeted directly or indirectly via its intracellular signaling pathway (e.g., STAT-1). Tumor Necrosis Factor-α The use of TNF-α inhibitors has revolutionized the tre...
Pretreatment of mice with IFN-alpha, IFN-beta, and IFN-lambda induced a strong expression of the negative regulator ubiquitin-specific peptidase 18 in the liver and gut. As a result, IFN-alpha signaling was significantly reduced when mice where reinjected 16 hours after the first injection. ...
W. et al. Novel growth and death related interferon-stimulated genes (ISGs) in melanoma:greater potency of IFN-beta compared with IFN-alpha2. J. Interf. Cytok. Res. 23, 745–756 (2003). Article CAS Google Scholar Douam, F. et al. Type III interferon-mediated signaling is critical ...