These effects may be mediated by the actions of IFN-alpha on dopamine (DA) metabolism in the basal ganglia. Diminished conversion of phenylalanine (Phen) to tyrosine (Tyr), the primary amino acid precursor of DA, has been associated with inflammation, and may reflect decreased activity of the...
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et al.The prognostic significance of Wilms' tumor gene 1 (WT1) expression at diagnosis in adults with Ph-negative B cell precursor acute lymphoblastic leukemia.Ann. Hematol.(2019).
Stromal-derived factor-1 in human tumors recruits and alters the function of plasmacytoid precursor dendritic cells. Nat Med., 7 (2001), pp. 1339-1346 Google Scholar 39 Dzionek A, Sohma Y, Nagafune J, et al. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin,...
(Thermo Fisher) coupled with a Dionex LC. MS/MS spectra were collected for the selected precursor ion within a 0.02-Da mass isolation window. Spectral data were then searched using Proteome Discoverer 1.4 against a UniProt protein database. The peptide spectrum matches (PSMs) for HOIP were ...
[70]. Endocytosis anomalies such as enlarged endosomes in neurons were identified as an early neuropathological feature in the brain of Ts65Dn mice and individuals with DS and Alzheimer’s disease [71,72]. Over-expressedItsn1and amyloid beta (A4) precursor protein (App) may contribute to ...
production can also be induced by il-18, a cytokine recently cloned from the spleens of mice inoculated with propionibacterium acnes and later challenged with lipopolysaccharide. 19 il-18 is secreted in a precursor form, and processing by the enzyme caspase 1 is required for the active form of...
Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway J Biol Chem, 279 (2004), pp. 49523-49532 View PDFView articleGoogle Scholar 55 H Fukumoto, BS Cheung, BT Hyman, MC ...
(calgranulin A), AW238654, cDNA DKFZp564D193, AL049252.1, major histocompatibility complex, class II, DP beta 1, J03041.1, human leukocyte antigen C alpha chain, major histocompatibility complex, class I, C, AK024836.1, BCM-like membrane protein precursor, AF144235.1, CD14 antigen, M86511.1,...
The sequences of the corresponding precursor interferon polypeptides containing the human α-2b-interferon signal peptide are shown in SEQ ID NOS:1-5. Although the present invention is not limited to any particular mechanism, it is believed that the interferon variants were produced in duckweed by...