fed‐batch processintensified process“organized stress”scale‐upProcess intensification has been widely used for many years in the mammalian biomanufacturing industry to increase productivity, agility and flexibility while reducing production costs. The most commonly used intensified processes are operated ...
The process allows for the intensification of your fed-batch process through reduced production duration, and there is no effect on the growth or titer profile. In addition, the number of runs per year that can be scheduled in a production facility can be increased without the expa...
The batch penicillin reactor simulator (Birol et al., 2002) is probably the most important monitoring benchmark on a pharmaceutical process, and it has found widespread application. More recently, an advanced simulator for industrial penicillin fed-batch manufacturing has been proposed (Goldrick et ...
But authors are of the opinion that if LA titres are significantly enhanced by shifting from batch to fed-batch or continuous without compromising on yields and productivity, these modes should also be evaluated at a large-scale. Separation of LA from fermentation broth is a significant cost asso...
For this purpose, droplets containing the grown TpPa-NO2 particles were directly fed into another T-micromixer, where they spontaneously merged with a SnCl2 solution in DMA/EtOH (9:1, v/v) after careful optimization of the flow rates (Figure 1b). The merged droplets moved through a coiled...
gl ucose—fed sequenti al aerob ic sl udge blank et reactors. Chemical Engineering J ournal , 20 11 , 174 ( 1) :182—189 [ 6] Gao D.W.,Liu L.,Liang H.,et a1.Comparison of fou r enhancement strategies for aerobi c granul ati on in se— quencing batch reactors....
Chinese hamster ovary clones cultured using an intensified high inoculation density fed-batch platform process. Continuous monitoring of residual metabolite concentrations facilitated automated feed-rate adjustment of three supplemental feeds to maintain glucose, phenylalanine, and methionine at desired setpoints...
Pulsed fed-batch processA process has previously been optimized for production of lactic acid from recycled paper sludge (RPS), the ultimate solid waste obtained in the wastewater treatment plant of a local paper recycling mdoi:10.1007/s13399-016-0211-0Marques, S....
N1 seed process intensification can be achieved by either non-perfusion (enriched-batch or fed-batch) or perfusion culture to reach those higher final N1 viable cell densities (VCD). In this study, we evaluated how different N1 intensification strategies, specifically enriched-batch (EB...
When the reaction process started in the membrane reactor, pure hydrogen was fed into the reactor to initially produce the desired pressures on the retentate and permeate sides. Soon after, a sharp rise in temperature up to 300 °C was observed inside the membrane reactor. Since the preparation...