In summary, the present results suggest that the integrin-mediated signaling pathway plays an important role in cell survival and G to S phase transition promoted by Gd-containing particles by enhancing focal adhesion formation. The results presented here provide novel evidence to advance knowledge ...
Integrins are important cell surface adhesion molecules,which are responsible for extra-and intra-cellular signal communication and transduction. Integrins are not only indispensable part in a variety of physiological activities in mammals,such as the immune response,cell adhesion and migration,tissue forma...
Herein we report that the αvβ6 integrin expressed in colon cancer cells induces gelatinase B secretion through the C-terminal cytoplasmic extension unique to the β6 integrin subunit, and that this ligand-independent event involves activation of the protein-kinase-C pathway.关键词:...
unrecognized complex between the soluble protein netrin-4 and laminin 纬1 subunit that in turn activates an 伪6尾1 integrin-mediated signaling pathway in ... FI Staquicini,E Dias-Neto,J Li,... - 《Proceedings of the National Academy of Sciences》 被引量: 146发表: 2009年 A complex of ...
To analyse the underlying mechanisms specific for β1-integrins, wild-type β1A-integrin-expressing GD25β1A cells were compared to GD25β1B cells, which express signaling-incompetent β1B variants. Cells grown on fibronectin, collagen-III, β1-integrin-IgG or poly-l-lysine were exposed to ...
elegans development (Kemphues et al., 1988), and our results show that mPar6C and PKCζ are involved in a signaling pathway directly responsible for the establishment of polarity during migration of mammalian cells. Furthermore, we show that the kinase activity of PKCζ is essential for ...
Cyclooxygenase-2 enhances α2β1 integrin expression and cell migration via EP1 dependent signaling pathway in human chondrosarcoma cells Background Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG) synthase, has been implicated in tumor metastasis. Interaction of COX-2 with... JF...
S113The influenza virus activates TGF via an αV6-integrin mediated pathway Toll-like receptors (TLRs) detect pathogens, such as influenza. TLR3 activation has been found to increase RhoA activity. We previously showed that RhoA is a key intermediary in avβ6 integrin-mediated TGFβ activation....
Haematopoietic cells and platelets employ G-protein-coupled receptors (GPCRs) to sense extracellular information and respond by initiating integrin-mediated adhesion. So far, such processes have not been demonstrated in non-haematopoietic cells. Here, we
内容提示: Regular ArticleSplice variants of Tissue Factor and integrin-mediated signalingRamprasad Srinivasan, Vladimir Y. Bogdanov⁎Division of Hematology/Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USAa b s t r a c ta r t i c l ei...