Integrins are an important family of cell surface receptors that mediate adhesive interactions between cells and the extracellular matrix (ECM). These transmembrane glycoproteins are composed of non-covalently associated - and β-subunit heterodimers. In mammals, there are currently 16 different -chains ...
Integrin functions are dependable on a delicate balance between active and inactive status via multiple mechanisms, including protein-protein interactions, conformational changes, and trafficking. Due to their exposure on the cell surface and sensitivity to the molecular blockade, integrins have been ...
Integrins: a family of cell surface receptors. Cell 48, 549–554 (1987). Article CAS PubMed Google Scholar Ruoslahti, E. & Pierschbacher, M. D. New perspectives in cell adhesion: RGD and integrins. Science 238, 491–497 (1987). Article ADS CAS PubMed Google Scholar Springer, T....
Researchers identified different types of mechanosensitive channels on the surface of bone cells, including classic Piezo and transient receptor potential vanilloid (TRPV) channels [88,89,90,91]. Osteocytes, OBs, and MSCs in the lacunar-canalicular system are the main cells for the transduction of ...
Integrins are heterodimeric cell surface receptors made up of a combination of 18 α and 8 β subunits, forming a family of 24 different members. Both α and β subunits contain a large extracellular domain, a short transmembrane domain, and usually a short cytoplasmic domain. Integrins play a...
Our results suggest that high-avidity binding between fertilin β (ADAM 2) and α6β1 requires cooperation between α6β1 and CD9. Such cooperation may assist sperm passage into the oviduct as well as sperm–egg interactions. 展开 关键词: tetraspan fertilin β cell adhesion ...
Among them, extracellular matrix-derived peptide motifs are an interesting biomimetic strategy to harness cell-surface interactions. Nonetheless, the combination of multiple peptide motifs in a controlled manner is essential to achieve receptor specificity and fully exploit the potentiality of synthetic ...
Cell-surface regulation of |[beta]|1-integrin activity on developing retinal neurons INTEGRINS are a family of αβ heterodimeric receptors that mediate cell-cell and cell-substratum interactions. Integrin binding to extracellular ligands r... KM Neugebauer,LF Rekhardt - 《Nature》 被引量: 2864发...
Homo- and hetero-oligomeric interactions between the transmembrane (TM) helices of integrin α and subunits may play an important role in integrin activation and clustering. As a first step to understanding these interactions, we used the TOXCAT assay to measure oligomerization of the wild-type α...
Among these potential targets are integrins, a family of cell surface transmembrane receptors that have important roles in cell-to-cell and cell-to-extracellular-matrix (ECM) interactions6. Activation of integrins also controls the morphology, polarity and migration of cells by engaging the cells to...