biology Article Integrin Adhesion Complex Organization in Sheep Myometrium Reflects Changing Mechanical Forces during Pregnancy and Postpartum Bryan A. McLendon 1,†, Avery C. Kramer 1,†, Heewon Seo 1 , Fuller W. Bazer 2, Robert C. Burghardt 1,* and Gregory A. Johnson 1,* 1 ...
5.1. ITGA6 Role in Hypoxia A tumor is a complex biomass encompassing diverse cancer cells, the tumor microen- vironment, stroma, and immune cells infiltrating the tumor [93]. When the tumor is still relatively small and undetectable in the body, the major route of transportation for neces-...
Talin has been suggested as a scaffolding protein that holds multiple integrin-associated proteins and the cytoskeleton together at the focal adhesions as a large complex, triggering a series of intracellular events and cell motility [42]. Hence, talin is widely considered to be a more potent ...
Taken together, these findings support the role for LMP1 in the early stages of NPC pathogenesis, by driving an EMT-like programme of transcriptional reprogramming through engaging a network of overlapping signalling pathways in a complex fashion, to promote survival and metastasis. 2. Results 2.1....
The proposed hypothesis is that cations may bind to an adjacent MIDAS (ADMIDAS), generating complexes that are slightly different depending on the metal. For Ca2+ and Mg2+, the complex between compound 17 and the β I-like domain can bind to αL I domain, inducing a switch to the open...
Data were normalized to the housekeeping gene succinate dehydrogenase complex subunit A (SDHA). Primer-BLAST (National Center for Biotechnology Information (NCBI), Bethesda, MD, USA) was used to design the primers which were made by IDT (Integrated DNA Technologies, Inc., Coralville, IA, USA)...
The structure of an activated integrin complex in its open state can be represented by the αIIBβ3 crystal structure (PDB ID 3fcu; [13]). Interestingly, up to now, only the α6 subunit has been identified to form a functional heterodimer with β4 [7,14]. Moreover, all integrins ...