PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis. Nat Commun 7, 12502 (2016).Martin K, Pritchett J, Llewellyn J, Mullan AF, Athwal VS, Dobie R, Harvey E, Zeef L, Farrow S, Streuli C, et al. PAK proteins and YAP-1 signalling ...
Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding. J Cell Biol. 1999;147:417–34. https://doi.org/10.1083/jcb.147.2.417. Article CAS PubMed PubMed Central Google Scholar Wiche G. Plectin in ...
Serine/threonine-protein kinase proteins, also known as P21-activated kinase (PAK), and the mechanosensitive factor, Yes-associated protein 1 (YAP-1) are core mediators of pro-fibrotic integrin beta-1 signalling, with YAP-1 capable of perpetuating integrin beta-1 expression. Pharmacological ...
Integrins, which consist of two non-covalently linked α and β subunits, play a crucial role in cell–cell adhesion and cell-extracellular matrix (ECM) interactions. Among them, integrin β1 is the most common subunit and has emerged as a key mediator in cancer, influencing various aspects o...
[157]. Similar to bone metastasis of prostate cancer, Tenascin-C and its receptor integrin α9β1were essential factors for lung metastasis of osteosarcoma cells by mediating transcription gene YAP [158]. In addition, blocking integrin α2β1reduced Col I binding and directly inhibited the ...
Since the Hippo/YAP signaling pathway was remarkably regulated by αvβ6, it raised the question of whether it mediates αvβ6’s regulatory effects on IL-34 expression and macrophage infiltration after kidney injury. To explore this, we added XMU-MP-1, a YAP agonist that could activate YAP...
YAP Yes-associated protein 1 ZO2 zonula occludens 2 1. Introduction Integrins are a large family of membrane receptors of which many of the members bind specifically to extracellular matrix molecules such as fibronectin, vitronectin and other RGD containing ligands, as well as various types of col...
To further assess these repressive effects, we found that PAI-1 induced a signaling cascade of GP130-SRC-YAP interactions, leading to increased expression of DNA-methyltransferase 1 (DNMT1) (Figure S4; Table S1). The upregulation in DNMT1 may contribute to its increased recruitment to the ...
of integrin α2β1 efficiently improved the outcome of chemotherapy and radiotherapy, which suggests new approaches for eradicating tumors in the clinic [21]. The integrin α11β1-Src-YAP1 signaling pathway is involved in resistance of melanoma to MAPK and PI3K/mTOR dual-targeted therapy [22]....
Growing evidence indicates that cell adhesion to extracellular matrix (ECM) plays an important role in cancer chemoresistance. Leukemic T cells express several adhesion receptors of the β1 integrin subfamily with which they interact with ECM. However, t