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(NIMH-IRP), National Institutes of Health, US Department of Health and Human Services, Building 35, Room 1A-100, 35 Convent Drive, Bethesda, MD 20892, USA, Tel: +1 301 451 4258, Fax: +1 301 402 7094, E-mail: akulan@mail.nih.gov 3Current address: PharmaTherapeutics Clinical Research...
Phenotypes, mechanisms and therapeutics: insights from bipolar disorder GWAS findings Ming Li Tao Li Yiru Fang Molecular Psychiatry (2022) Human forebrain organoids reveal connections between valproic acid exposure and autism risk Qingtuan Meng Wendiao Zhang Chao Chen Translational Psychiatry (2022...
Therefore, as for any new drug candidate, it is of utmost importance to monitor the possible adverse events of anti-integrin therapeutics and to identify a safe therapeutic window. Encouragingly, the abovementioned RGD-binding integrin inhibiting drug candidates all have shown a favourable safety ...
In addition to DNA methylation, somatic mutations in genes might affect their expression, stability, and function, as well as the design of target-specific therapeutics. Therefore, we investigated the frequency of somatic variants including point mutations and small indels in the candidate target genes...
In addition, its mode of "network targets and multi-component therapeutics" matches well with the holistic philosophy of TCM [22]. Thus, network pharmacology approaches have been verified as effective for elucidating the potential therapeutic mechanisms of TCMs [23], [24], [25], [26], [27]...
In the future, UCSCXenaShiny remains committed to facilitating transformative insights that drive advancements in cancer biology and therapeutics with the ever-changing landscape of cancer omics studies. Methods Omics datasets curation from UCSC Xena We have curated multi-omics pan-cancer datasets from ...
Data integration enabled us to build, refine, and validate high-quality cell-type-specific models. While many of the major pathways important for CD4+T-cell activation and proliferation are commonly active across different CD4+T-cell subtypes we tested, the models differ with respect to how these...