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A few days later, a very old employee in the finance department of the factory came to see me. He had bad intercostal neuralgia. He said he had had three onsets: the first had been cured by a famous TCM doctor, Shi Xiaoshan (石筱山); the second was cured by another famous doctor —...
Adult male C57BL/6 specific pathogen-free mice (25–30 g) were provided by the Animal Experimental Center of Central South University, China. The animals were housed under controlled conditions (temperature, 23 °C ± 2 °C; relative humidity, 50% ± 10%; 12 h light/darkness) ...
It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence expression of PrCa target genes. To
Cervical cancer is the leading cause of death among women with cancer worldwide. Here, we performed an integrative analysis of Illumina HumanMethylation450K and RNA-seq data from TCGA to identify cervical cancer-specific DNA methylation markers. We first
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andBijrepresents the occurrence peakiin cellj. MatrixWrepresents the regulatory potential matrix, andWijrepresents the weight of regulatory potential of each peakito each genejcalculated from an exponential function on the distance between the center of peakiand the transcription start site of genej(...
Most of these TF binding targets come from non-neuronal cell lines, and many come from proliferating cells (most ENCODE lines are cancer cell lines). We therefore cautiously interpret this experimental support for our binding sites, but find it encouraging that a moderate to large fraction of ...
In this tutorial, we provide an overview of computational analysis of bulk RNA-seq data for immune characterization of tumors and introduce commonly used computational tools with relevance to cancer immunology and immunotherapy. These tools have diverse functions such as evaluation of expression ...