First, using random forest-based feature selection method multi-omics data are integrated to identify key regulatory factors that affect gene expression, and then genome-wide regulatory networks are constructed. Next, by comparing the regulatory networks of key candidate genes in variant samples and ...
D. et al. Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes. Nat. Genet. 47, 106–114 (2015). Article Google Scholar Silverbush, D. et al. Simultaneous integration of multi-omics data improves the identification of cancer driver...
Network-basedintegrationofmulti-omicsdata forprioritizingcancergenes ChristosDimitrakopoulos 1,2 ,SravanthKumarHindupur 3 ,LucaHa¨fliger 1 , JonasBehr 1,2 ,HesamMontazeri 1,2 ,MichaelN.Hall 3 and NikoBeerenwinkel 1,2, * 1 DepartmentofBiosystemsScienceandEngineering,ETHZu¨rich,Basel,Switzerland,...
Omics approaches are widely applied to investigate physiological processes and pathological conditions. Many public data repositories make it possible to extract data for their analyses, comparisons and integrations, provided the availability of suitable tools. Our interest is oriented to the integration of...
The formation of complex traits is the consequence of genotype and activities at multiple molecular levels. However, connecting genotypes and these activities to complex traits remains challenging. Here, we investigate whether integrating genomic, transc
We used Random Forest regression for integrating multiple ~ omics data for prediction of four quality traits of potato: tuber flesh colour, DSC onset, tuber shape and enzymatic discoloration. For tuber flesh colour beta-carotene hydroxylase and zeaxanthin epoxidase were ranked first and forty-...
作者:Dimitrakopoulos C, Hindupur SK, Häfliger L, Behr J, Montazeri H, Hall MN, Beerenwinkel N. 杂志:Bioinformatics. 时间:2018 Jul 15. 目标: 主要内容:
Multi-omics factor analysis-a framework for unsupervised integration of multi-omics data sets. Mol Syst Biol. 2018;14(6):e8124. https://doi.org/10.15252/msb.20178124. Article CAS PubMed PubMed Central Google Scholar Argelaguet R, Arnol D, Bredikhin D, Deloro Y, Velten B, Marioni JC...
Omics data provide deep insights into overall biological processes of organisms. However, integration of data from different molecular levels such as transcriptomics and proteomics, still remains challenging. Analyzing lists of differentially abundant mo
These signatures have been characterized by different approaches based on mutational, pharmacological and clinical evidences, demonstrating the validity of our selection. Moreover, we define new pharmacological strategies validated by in vitro experiments that show inhibition of cell growth in two tumour ...