Rather than a Stata program to define the likelihood the user needs to write a Python function. Automatic differentiation is used so the gradient and Hessian functions are calculated automatically using Jax. Likelihood, gradient and Hessian functions are compiled so fast and can make use of ...
Grid is a simple, free, and open-source Python library for numerical integration, interpolation and differentiation. Primarly intended for the quantum chemistry community to assist in density-functional (DFT) theory calculations, including support for periodic boundary conditions. Please visit Grid Docume...
statisticscsharpintegrationmathfsharpinterpolationrandommatrixlinear-algebraregressionfftnumericsdifferentiationmathnet UpdatedMar 3, 2025 C# ACI.dev is the open source platform that connects your AI agents to 600+ tool integrations with multi-tenant auth, granular permissions, and access through direct functi...
et al. A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation. Blood 128, e20–e31 (2016). Article CAS Google Scholar Baron, M. et al. A single-cell transcriptomic map of the human and mouse pancreas reveals inter- and intra-cell population structure. ...
(marked byTYROBPandCTSS; Fig.6c). This differentiation trajectory is consistent with the well-known developmental pathways of myeloid cells in bone marrow53, demonstrating that MIDAS’s 32-dimensional biological state latent variables can be applied to trajectory inference of cell differentiation. It ...
We propose that a shift in the epithelial stem cell state alters the differentiation pathway from healthy to metaplastic lineages, which in turn contribute to ongoing inflammation in chronic disease. Pan-gastrointestinal data integration We curated, integrated and harmonized healthy cells across the ...
Integration of human papillomavirus (HPV) into the host genome drives HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC). Whole-genome sequencing of 51 tumors revealed intratumor heterogeneity of HPV integration, with 44% of breakpoints subc
Tables (1) Table Extras (2) Download all Table S1. Detailed steps for cell-type harmonization and integration using the CellHint algorithm, related to Figure 1 Table S2. List of organs and datasets used for constructing the multi-organ single-cell resource, related to Figure 7Volume...
The prolactin signaling pathway participated in the adipogenesis, differentiation of brown adipocytes, and metabolism of glucose and lipids.[Citation69] By acting on adipose tissue and the pancreas, prolactin plays a pivotal role in the balance of energy. The activation of cAMP signaling pathway ...
Using the RNA-seq data, we identified an HPV integration site in TCGA-BA-A4IH at chr9:99,952,156. The transcriptome and chromatin accessibility of this patient differed greatly from the other 8 patients at the HPV integration site (Fig. 2). The other 8 patients lacked transcription (RPM<...