INHIBITORS OF THE HIV INTEGRASE ENZYMEThe present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus ("HIV") integrase enzyme.Klaus Ruprecht Dress...
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英:['ɪntɪgreɪs] 美:['ɪntɪgreɪs] integrase是什么意思 n.[生化]整合酶 integrase英英释义 Integrase Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that enables its genetic material to be integrated into the DNA of the infected cell. Retroviral ...
可溶性hiv-1整合酶重组蛋白的制备方法 Soluble hiv-1 integrase enzyme preparation of recombinant proteinsdoi:CN103275945 A可溶性HIV-1整合酶重组蛋白的制备方法,属于生物技术领域. Soluble recombinant HIV-1 integrase protein preparation, which belongs to the field of biotechnology. 制备方法包括诱导表达,菌体...
英['ɪntɪgreɪs] 美['ɪntɪgreɪs] 是什么意思 n. 整合酶; 英英释义 Integrase Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that enables its genetic material to be integrated into the DNA of the infected cell. Retroviral INs are not to be co...
The integrase enzyme is essential for virus replication and disease progression, therefore, inhibitors of this enzyme may be valuable in the treatment of AIDS. The extract derived from the fermentation broth of a soil- derived fungal culture of Aspergillus flavipes was found to be active. ...
An integrase inhibitor is a new class of anti-HIVdrugs that targets the enzyme integrase. As of early 2010, one member of this class has been approved for commercial use in the United States. Raltegravir, also known as Isentress®, has advanced the treatment of HIV infection, since it tar...
Integrase Strand Transfer Inhibitors (INSTIs) played a pivotal role in sus- tained viral suppression, which disrupted the viral life cycle by inhibiting the integrase enzyme, leading to rapid viral load reduction [5]. Recent studies have emphasized the efficacy of second-generation INSTIs like bic...
HIV Integrase (IN) is an enzyme that is responsible for the integration of the proviral genome into the human genome, and this integration step is the first step of the virus hijacking the human cell machinery for its propagation and replication. 10-23 DNAzyme has the potential to suppress ...
Integration of the viral genome into host cell chromatin is a pivotal and unique step in the replication cycle of retroviruses, including HIV. Inhibiting HIV replication by specifically blocking the viral integrase enzyme that mediates this step is an obvious and attractive therapeutic strategy. After...