High-resolution mass spectrometry (HRMS)SomatropinIntact protein analysisImmunocaptureMass extraction window (MEW)DeconvolutionThe quantitative determination of intact proteins in biological samples by LC with high-resolution MS detection can be a useful alternative to ligand-binding assays or LC-MS-based ...
Join mass spectrometry expert Dr. Stephane Houel as he presents this poster on the characterization of antibody drug conjugates using intact protein mass spectrometry, at the American Association of Pharmaceutical Scientists (AAPS) convention.
Intact Protein Analysis Peptide Sequencing by Mass Spectrometry Limited Proteolysis The science of measuring proteins Intact protein analysis is performed for a number of reasons, including determination of molecular mass (during top-down analysis...
Intact-MS (Intact protein mass spectrometry) technology is used to determine the exact mass of protein molecules, and it is an ideal method to screen covalent binding compound library. When a compound is covalently bound to the protein, the corresponding molecular weight of the protein molecule wi...
Protein-protein interactions, including aggregation, are “relatively simple to identify,” adds Chen. As long as these species, originating in solution phase, remain intact in the gas phase under MS conditions, “you can use the measured masses and work out from the stoichiometry species...
Mass spectrometry technology to detect and characterize large, intact protein complexes is becoming more accessible.
Intact protein mass spectrometry and top-down proteomics Whitelegge,Julian - 《Expert Review of Proteomics》 被引量: 0发表: 2013年 Intact protein mass spectrometry and top-down proteomics Expert Rev. Proteomics 10(2), 127-129 (2013) American Society for Mass Spectrometry Sanibel meeting on top-...
One gene can give rise to many functionally distinct proteoforms, each of which has a characteristic molecular mass. Top-down mass spectrometry enables the analysis of intact proteins and proteoforms. Here members of the Consortium for Top-Down Proteomic
Capillary electrophoresis-mass spectrometry for the analysis of intact proteins. Journal of Chromatography A. 2007;1159:81-109R. Haselberg, G.J. de Jong, G.M. Sonmsen, Capillary electrophoresis-mass spectrometry for the analysis of intact protein, J. Chromatogr. A 1159 (2007) 81-109....
In this study, we report the application of intact mass spectrometry approaches to rapidly assess the outcome of X-ray footprinting experiments at the XFP beamline using lysozyme as a simple test protein. These top-down results are compared to Alexa488 dose-response data and bottom-up proteomics...