The secretion ratios of insulin and C-peptide at 1, 2, and 3 h were calculated by comparison with their values at 0 h. We used logistic regression analysis to establish the predictive models and compared the diagnostic efficiency by receiver operating characteristic analysis. Results: The fasting...
Biochemical investigations during hypoglycemic episodes revealed elevated C-peptide and insulin levels, consistent with endogenous hyperinsulinemia. Imaging studies, including contrast-enhanced computed tomography (CECT) and Ga-DOTATATE scan, confirmed a hyper-enhancing lesion in the distal body of the ...
Blood tests and suppression tests. To find out if you have an insulinoma, your doctor will test your blood sugar, insulin, C-peptide, and proinsulin during a 72-hour rest. This will confirm that: You have symptoms of low blood sugar, especially after not eating or heavy exercise Your bloo...
Serum insulin, proinsulin, and C-peptide concentrations were 21.1 µU/mL, 16.9 pmol/L, and 2.72 ng/mL, respectively. Subsequent intravenous administration of 1 mg of glucagon increased the plasma glucose concentration to 76 mg/dL (4.2 mmol/L). Moreover, the insulin-to-C-peptide molar ...
(CT) scans of the pancreas were unremarkable. The patient had gained 3 to 4 kg in the past 3 years. After admission, a 5 h-OGTT showed a blood glucose level of < 3 mmol/L, an insulin level of > 3 mU/L and a C-peptide level of > 0.6 ng/mL, with ...
At admission, results showed inappropriately elevated insulin, C-peptide and proinsulin levels despite significant hypoglycemia. CT scan showed “cystic” nodes in the pancreas and in the liver. Liver biopsy found a well-differentiated neuroendocrine carcinoma with positive staining for chromogranin A and...
The amounts of immunoreactive proinsulin (IRP), immunoreactive insulin (IRI), and C-peptidelike immunoreactivity (CPR) in six insulinomas and one nesidioblastosis lesion were determined together with those in the surrounding pancreatic tissue. Four non-insulinoma and nondiabetic human pancreases were...
Proinsulin and C-peptide: a review. The recent work on proinsulin and C-peptide has been reviewed with major emphasis on the most significant findings since 1972. Proisulin has now been estab... AE Kitabchi - 《Metabolism Clinical & Experimental》 被引量: 182发表: 1977年 Insulin, C-peptid...
2-NBDLG (23003-v, Peptide Institute), 2-NBDG (23002-v, Peptide Institute), and 2-TRLG were provided by Peptide Institute Inc. and used as described previously [17]. Carbenoxolone (C4790, Sigma) was used to block gap junction/hemi-channel. Phloretin (P7912, Sigma), cytochalasin B (...
Upon presentation, Whipple's triad was confirmed, and biochemical testing revealed hyperinsulinemic hypoglycemia (plasma glucose: 27 mg/dL, serum insulin: 45.83 mIU/L, C‐peptide: 7.03 ng/mL). Imaging identified a 3 × 3 cm hypervascular lesion in the pancreatic tail. The patient underwent ...