Basal/Bolus Insulin Therapy: A Need for Two Daily NPH DosesIGOR BJELINSKIIVANA PAVLICRENARDIJANA BJELINSKIZELJKO METELKO
Comparison of the effects on glucose and lipid metabolism of equipotent doses of insulin detemir and NPH insulin with a 16-h euglycemic clamp. Diabetologia 2005; 48: 420-426.Hordern SV, Wright JE, Umpleby AM, et al. Comparison of the effects on glucose and lipid metabolism of equipotent ...
poursuivi depuis 36 mois et le contrôle métabolique est assez satisfaisant (7,6 %). Abbreviations: CSII, Continuous subcutaneous insulin infusion; IgE, Immunoglobulin E; NPH, Neutral protamine Hagedorn; IV, intravenous; T1D, type 1 diabetes. ∗ Corresponding author. Tel.: +33 1 40 03...
of action, this being longer than NPH insulin, but approaching 24 h only at clinically high doses. As a result of this, most of the original clinical studies of insulin detemir, especially in T1DM, were conducted using twice daily dosing and insulin detemir was therefore initially licensed for...
achieved with neutral protamine Hagedorn (NPH) insulin, with significantly less risk of hypoglycemia, particularly at night. 2---4 These compounds are also characterized by a lower day-to-day variability in fasting plasma glucose levels. 5---7 However, these insulins are not able to accura...