Flow chart and design concerning the participants enrolled in the current nutritional intervention Full size image The procedures applied in the DIOGenes trial were in agreement with the Declaration of Helsinki and were approved by the local ethic committees corresponding to each participating country. An...
Hyperinsulinemia is also an independent risk factor for EC [12] and ovarian cancer [22], although associations between different types of ovarian cancer and hyperinsulinemia are less understood. Give the links between abnormal endometrium and conditions associated with hyperinsulinemia, we hypothesized ...
Data Sources and Preprocessing Procedures The AGA dataset was obtained from the Genome-Wide Association Studies (GWASs) database (https://gwas.mrcieu.ac.uk/), encompassing a total of 212,453 AGA samples and 8,885,805 SNPs specific to the AGA population. For fasting insulin analysis, the sa...
Flow chart for eligibility screening and inclusion of the study population. T2D type 2 diabetes, T1D type 1 diabetes Full size image The participants’ baseline characteristics were summarized in Table 1. Compared with the patients who did not receive early insulin therapy, the patients who receive...
affiliated phylum. After 6-month MK-7 intervention accompanied by their corresponding baseline status. Node is based on the degree of connectivity. Blue dashed and orange edges indicate positive correlations in the NC group and VK group and gray edges indicate negative correlations.FDumbbell chart ...
Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible humans, underscoring its important role in the complex pathogenesis of this disease. Insulin resistance contributes to multiple tissue defects characteristic of T2
Like many other cell types, human ovarian granulosa cells also display mitogenic responses to insulin/IGF-1. One measure of such a response is [3H]thymidine incorporation into total DNA. [3H]thymidine incorporation was stimulated by insulin in a dose-dependent manner. Basal [3H]thymidine incorpora...
u, Distribution of pancreatic islet cell clusters from RD (left chart) and HFD (right chart) fed male mice. v, UMAPs representing expression of known marker genes across the cell clusters Ins1 (beta cells), Gcg (alpha cells), Sst (delta cells), Ftl1 (endothelial cells), Ppt (gamma ...
and the selection process is shown in a PRISMA flow chart in Fig.1. The appraisal scores are presented in Additional file2. Where available, the survey response-rate has been entered although this was not available in many of the surveys which were reported online. Survey limitations include ...
Tissue was coded, processed to paraffin blocks, cut as 6 μm sections, immunostained using an antibody to PGP 9.5 (1:1000, Biogenesis Ltd. Poole, UK) and the number of immunoreactive IENF and sub-epidermal nerve profiles (SNP) per unit length quantified under light microscopy [41]. 2.4....