These work within 5 to 15 minutes and peak within 1 to 2 hours. Larger dosages of insulin analogs affect the duration of action, for example, a few units may last less than 4 hours, whereas 25 to 30 units may last 5 to 6 hours. However, a larger dose does not affect the onset ...
Although there is general agreement that insulin receptor tyrosine kinase activity mediates many of the actions of insulin, two types of studies suggest th... CK Sung - 《Journal of Cellular Biochemistry》 被引量: 66发表: 1992年 加载更多研究点推荐 Insulin Receptor Kinase Insulin Insulin Action in...
Apart from this difference, 023 and DS-7 cells showed comparable insulin binding characteristics, which are similar to those observed in other cell types. Insulin at a concentration of 1 μ g/ml (167 nM) was found to stimulate 3-O-methylglucose uptake by ≈ 50% in glucose-fed cells of ...
Impaired glucose tolerance (IGT) is associated with defects in both insulin secretion and action and carries a high risk for conversion to non-insulin-depe... MK Cavaghan,DA Ehrmann,MM Byrne,... - 《Journal of Clinical Investigation》 被引量: 529发表: 1997年 Interleukin-1 effect on glycemia...
Insulin induces a wide variety of growth and metabolic response in many cell types. Insulin initiates its biological effects by activation of tyrosine kinase in the beta-subunit and phosphorylates several proteins, such as insulin receptor substrate-1 (IRS-1), Shc. thereby activating phosphatidyl ino...
Going forward, a better understanding of the integrated network of cell types and pathways upstream and downstream of insulin in adipose tissue could lead to approaches to enhance systemic insulin sensitivity to prevent and improve the treatment of type 2 diabetes. Acknowledgments The authors thank ...
The observation that insulin has an additive effect with KL and LIF, but not bFGF, suggests the insulin's site of action is likely the oocyte. In summary, observations suggest that insulin acts as an endocrine type factor to help coordinate primordial to primary follicle transition at the ...
Action de la sécrétion interne du pancréas sur différents organes et en particulier sur la sécrétion rénale. Arch. Fisiol. 7, 96–99 (1909). Google Scholar Lindsten, J. August Krogh and the Nobel Prize to Banting and Macleod. The Nobel Prize https://www.nobelprize.org/prizes/...
ARTICLE Insulin exerts direct, IGF-1 independent actions in growth plate chondrocytes Fengjie Zhang1,2, Qiling He3, Wing Pui Tsang1,2, W Timothy Garvey4, Wai Yee Chan1,2 and Chao Wan1,2 Insufficient insulin production or action in diabetic states is associated with growth retardation and ...
An over-expression of IAPP relative to insulin may therefore be involved in diabetes pathogenesis, contributing to its metabolic perturbations, possibly through the capacity of IAPP to restrain insulin release and action and to form islet amyloid. 展开 ...